Leukoplakia of the maxillary vestibule--an association with Viadent?

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999 Jan;87(1):61-6. doi: 10.1016/s1079-2104(99)70296-9.

Abstract

Objective: This report investigates a possible correlation between chronic use of Viadent products and the subsequent development of leukoplakia in the maxillary vestibule.

Study design: A retrospective review of 88 patients with leukoplakia of the maxillary vestibule is presented. Prevalence of Viadent use was determined in this group and in a group of 100 randomly selected adults who presented themselves for routine preadmission screening at a dental school.

Results: Of the patients diagnosed with leukoplakia of the maxillary vestibule, 84.1% reported having used Viadent, whereas the prevalence of use was only 3% in the 100 randomly selected adults.

Conclusions: Use of Viadent products appears to be associated with an increased prevalence of leukoplakia in the maxillary vestibule.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Alkaloids / adverse effects*
  • Benzophenanthridines
  • Female
  • Humans
  • Isoquinolines
  • Leukoplakia, Oral / chemically induced*
  • Male
  • Maxilla
  • Middle Aged
  • Mouth Mucosa / drug effects
  • Mouthwashes / adverse effects*
  • Retrospective Studies

Substances

  • Alkaloids
  • Benzophenanthridines
  • Isoquinolines
  • Mouthwashes
  • sanguinarine