The selective 5-HT1B receptor inverse agonist SB-224289, potently blocks terminal 5-HT autoreceptor function both in vitro and in vivo

Ann N Y Acad Sci. 1998 Dec 15:861:270-1. doi: 10.1111/j.1749-6632.1998.tb10219.x.
No abstract available

MeSH terms

  • Animals
  • Body Temperature Regulation / drug effects
  • CHO Cells
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / physiology*
  • Cricetinae
  • Dentate Gyrus / drug effects
  • Dentate Gyrus / physiology
  • Guanosine 5'-O-(3-Thiotriphosphate) / metabolism
  • Guinea Pigs
  • Humans
  • Oxadiazoles / chemistry
  • Oxadiazoles / pharmacology*
  • Piperazines / chemistry
  • Piperazines / pharmacology*
  • Piperidones / chemistry
  • Piperidones / pharmacology*
  • Receptor, Serotonin, 5-HT1B
  • Receptors, Serotonin / drug effects
  • Receptors, Serotonin / physiology*
  • Recombinant Proteins / drug effects
  • Recombinant Proteins / metabolism
  • Serotonin / metabolism
  • Serotonin Antagonists / pharmacology*
  • Spiro Compounds / chemistry
  • Spiro Compounds / pharmacology*
  • Sumatriptan / pharmacology
  • Transfection

Substances

  • HTR1B protein, human
  • Oxadiazoles
  • Piperazines
  • Piperidones
  • Receptor, Serotonin, 5-HT1B
  • Receptors, Serotonin
  • Recombinant Proteins
  • SB 22489G
  • Serotonin Antagonists
  • Spiro Compounds
  • GR 127935
  • Serotonin
  • Guanosine 5'-O-(3-Thiotriphosphate)
  • Sumatriptan