Abstract
The ready availability of xenografts and the promising results of genetic engineering both may offer new methods in peripheral xenotransplantation. FK506 and RS61443 are able to prolong survival of nerve xenografts. The incorporation of adenoviral sequences in xenogeneic tissues is possibly a new option for decreasing the toxicity of immunosuppressive drugs and immunogenicity of grafts.
MeSH terms
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Animals
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Cricetinae
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Genetic Therapy*
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Graft Survival / drug effects*
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Graft Survival / immunology
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Immunosuppressive Agents / pharmacology*
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Mice
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Mycophenolic Acid / analogs & derivatives*
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Mycophenolic Acid / pharmacology
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Peripheral Nerves / immunology
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Peripheral Nerves / transplantation*
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Rats
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Rats, Inbred Strains
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Tacrolimus / pharmacology*
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Transfection
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Transplantation, Heterologous / immunology*
Substances
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Immunosuppressive Agents
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Mycophenolic Acid
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Tacrolimus