Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors

T E Barta; M A Stealey; P W Collins; R M Weier

doi:10.1016/s0960-894x(98)00627-1

Antiinflammatory 4,5-diarylimidazoles as selective cyclooxygenase inhibitors

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3443-8. doi: 10.1016/s0960-894x(98)00627-1.

Authors

T E Barta¹, M A Stealey, P W Collins, R M Weier

Affiliation

¹ G.D. Searle and Co., Skokie, IL 60077, USA.

PMID: 9934449
DOI: 10.1016/s0960-894x(98)00627-1

Abstract

The synthesis and activity of a series of 4,5-diarylimidazole analogs are described. One analog had an IC50 of 80 nM, was 6750-selective against COX-1, and demonstrated in vivo potency in the mouse air pouch model.

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / chemistry
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
Cyclooxygenase Inhibitors / pharmacology*
Imidazoles / chemistry
Imidazoles / pharmacology*
Mice
Molecular Structure

Substances

Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase Inhibitors
Imidazoles