Methionine analogues as inhibitors of methionyl-tRNA synthetase

J Lee; M K Kang; M W Chun; Y J Jo; J H Kwak; S Kim

doi:10.1016/s0960-894x(98)00642-8

Methionine analogues as inhibitors of methionyl-tRNA synthetase

Bioorg Med Chem Lett. 1998 Dec 15;8(24):3511-4. doi: 10.1016/s0960-894x(98)00642-8.

Authors

J Lee¹, M K Kang, M W Chun, Y J Jo, J H Kwak, S Kim

Affiliation

¹ Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Korea.

PMID: 9934462
DOI: 10.1016/s0960-894x(98)00642-8

Abstract

A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with Ki = 19 microM and showed a growth inhibition against E.coli JM 109, P. vulganis 6059 and C. freundii 8090.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bacteria / drug effects
Bacteria / enzymology
Bacteria / growth & development
Enzyme Inhibitors / chemical synthesis
Enzyme Inhibitors / pharmacology*
Methionine / analogs & derivatives*
Methionine / chemical synthesis
Methionine / pharmacology
Methionine-tRNA Ligase / antagonists & inhibitors*
Microbial Sensitivity Tests

Substances

Enzyme Inhibitors
methionine-hydroxamate
Methionine
Methionine-tRNA Ligase