Abstract
The beta-chain repertoire of the T cells that infiltrate spontaneously regressing nevi (the halo nevus phenomenon) was studied. In addition to the infiltration of the halo nevi by cutaneous lymphocyte-associated Ag-positive lymphocytes, oligoclonal expansion of T cells was observed in all halo nevi of all patients. T cells using the same TCR beta-chain were observed in distinct halo nevi of the same patient but not in his peripheral blood, demonstrating a local expansion of common clones that are most likely activated by the Ag(s) shared by independent halo nevi of the same patient.
MeSH terms
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Amino Acid Sequence
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Antigens, Neoplasm
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Base Sequence
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Complementarity Determining Regions*
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DNA, Complementary / genetics
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Humans
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Immunoglobulin alpha-Chains / genetics
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Melanocytes / immunology*
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Melanocytes / pathology*
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Melanoma-Specific Antigens
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Molecular Sequence Data
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Neoplasm Proteins / genetics
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Nevus, Pigmented / genetics
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Nevus, Pigmented / immunology*
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Nevus, Pigmented / pathology*
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RNA, Messenger / genetics
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Receptors, Antigen, T-Cell, alpha-beta / genetics
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Sequence Homology, Amino Acid
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Skin Neoplasms / genetics
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Skin Neoplasms / immunology*
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Skin Neoplasms / pathology*
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T-Lymphocytes / immunology*
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T-Lymphocytes / pathology*
Substances
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Antigens, Neoplasm
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Complementarity Determining Regions
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DNA, Complementary
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Immunoglobulin alpha-Chains
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Melanoma-Specific Antigens
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Neoplasm Proteins
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RNA, Messenger
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Receptors, Antigen, T-Cell, alpha-beta