Abstract
Several monoacetyldiglycerides were synthesized from glycerol in search for new Ca2+ mobilizing agent in vitro. All monoacetyldiglycerides except linolenoyl and phenlycyclopropylcarbonyl derivatives showed activity toward Ca2+ release in pancreatic acinar cells. Linoleoyl and docosahexaenoyl derivatives were chosen for further test and exhibited unique activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholine / pharmacology
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Animals
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Calcium / metabolism*
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Calcium Signaling / drug effects
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Diglycerides / chemical synthesis
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Diglycerides / chemistry*
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Diglycerides / pharmacology*
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Molecular Structure
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Pancreas / cytology
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Pancreas / drug effects*
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Pancreas / metabolism
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Rats
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Structure-Activity Relationship
Substances
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Diglycerides
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Acetylcholine
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Calcium