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31 results

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Page 1
Identification of novel azaindazole CCR1 antagonist clinical candidates.
Harcken C, Kuzmich D, Cook B, Mao C, Disalvo D, Razavi H, Swinamer A, Liu P, Zhang Q, Kukulka A, Skow D, Patel M, Patel M, Fletcher K, Sherry T, Joseph D, Smith D, Canfield M, Souza D, Bogdanffy M, Berg K, Brown M. Harcken C, et al. Among authors: skow d. Bioorg Med Chem Lett. 2019 Feb 1;29(3):441-448. doi: 10.1016/j.bmcl.2018.12.024. Epub 2018 Dec 13. Bioorg Med Chem Lett. 2019. PMID: 30595446
N-Arylsulfonyl-α-amino carboxamides are potent and selective inhibitors of the chemokine receptor CCR10 that show efficacy in the murine DNFB model of contact hypersensitivity.
Abeywardane A, Caviness G, Choi Y, Cogan D, Gao A, Goldberg D, Heim-Riether A, Jeanfavre D, Klein E, Kowalski JA, Mao W, Miller C, Moss N, Ramsden P, Raymond E, Skow D, Smith-Keenan L, Snow RJ, Wu F, Wu JP, Yu Y. Abeywardane A, et al. Among authors: skow d. Bioorg Med Chem Lett. 2016 Nov 1;26(21):5277-5283. doi: 10.1016/j.bmcl.2016.09.047. Epub 2016 Sep 21. Bioorg Med Chem Lett. 2016. PMID: 27692854 Free article.
A High-Throughput Genetic Complementation Assay in Yeast Cells Identified Selective Inhibitors of Sphingosine Kinase 1 Not Found Using a Cell-Free Enzyme Assay.
Kashem MA, Kennedy CA, Fogarty KE, Dimock JR, Zhang Y, Sanville-Ross ML, Skow DJ, Brunette SR, Swantek JL, Hummel HS, Swindle J, Nelson RM. Kashem MA, et al. Among authors: skow dj. Assay Drug Dev Technol. 2016 Jan-Feb;14(1):39-49. doi: 10.1089/adt.2015.671. Epub 2015 Oct 1. Assay Drug Dev Technol. 2016. PMID: 26426296
A GPBAR1 (TGR5) small molecule agonist shows specific inhibitory effects on myeloid cell activation in vitro and reduces experimental autoimmune encephalitis (EAE) in vivo.
Lewis ND, Patnaude LA, Pelletier J, Souza DJ, Lukas SM, King FJ, Hill JD, Stefanopoulos DE, Ryan K, Desai S, Skow D, Kauschke SG, Broermann A, Kuzmich D, Harcken C, Hickey ER, Modis LK. Lewis ND, et al. Among authors: skow d. PLoS One. 2014 Jun 26;9(6):e100883. doi: 10.1371/journal.pone.0100883. eCollection 2014. PLoS One. 2014. PMID: 24967665 Free PMC article.
G protein-coupled bile acid receptor 1 stimulation mediates arterial vasodilation through a K(Ca)1.1 (BK(Ca))-dependent mechanism.
Fryer RM, Ng KJ, Nodop Mazurek SG, Patnaude L, Skow DJ, Muthukumarana A, Gilpin KE, Dinallo RM, Kuzmich D, Lord J, Sanyal S, Yu H, Harcken C, Cerny MA, Hickey ER, Modis LK. Fryer RM, et al. Among authors: skow dj. J Pharmacol Exp Ther. 2014 Mar;348(3):421-31. doi: 10.1124/jpet.113.210005. Epub 2014 Jan 7. J Pharmacol Exp Ther. 2014. PMID: 24399854
A new class of 5-HT2B antagonists possesses favorable potency, selectivity, and rat pharmacokinetic properties.
Moss N, Choi Y, Cogan D, Flegg A, Kahrs A, Loke P, Meyn O, Nagaraja R, Napier S, Parker A, Thomas Peterson J, Ramsden P, Sarko C, Skow D, Tomlinson J, Tye H, Whitaker M. Moss N, et al. Among authors: skow d. Bioorg Med Chem Lett. 2009 Apr 15;19(8):2206-10. doi: 10.1016/j.bmcl.2009.02.126. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19307114
5-Aminomethylbenzimidazoles as potent ITK antagonists.
Riether D, Zindell R, Kowalski JA, Cook BN, Bentzien J, Lombaert SD, Thomson D, Kugler SZ Jr, Skow D, Martin LS, Raymond EL, Khine HH, O'Shea K, Woska JR Jr, Jeanfavre D, Sellati R, Ralph KL, Ahlberg J, Labissiere G, Kashem MA, Pullen SS, Takahashi H. Riether D, et al. Among authors: skow d. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1588-91. doi: 10.1016/j.bmcl.2009.02.012. Epub 2009 Feb 8. Bioorg Med Chem Lett. 2009. PMID: 19246196
Synthesis and SAR studies of indole-based MK2 inhibitors.
Xiong Z, Gao DA, Cogan DA, Goldberg DR, Hao MH, Moss N, Pack E, Pargellis C, Skow D, Trieselmann T, Werneburg B, White A. Xiong Z, et al. Among authors: skow d. Bioorg Med Chem Lett. 2008 Mar 15;18(6):1994-9. doi: 10.1016/j.bmcl.2008.01.119. Epub 2008 Feb 6. Bioorg Med Chem Lett. 2008. PMID: 18291646
Pyrazinoindolone inhibitors of MAPKAP-K2.
Goldberg DR, Choi Y, Cogan D, Corson M, DeLeon R, Gao A, Gruenbaum L, Hao MH, Joseph D, Kashem MA, Miller C, Moss N, Netherton MR, Pargellis CP, Pelletier J, Sellati R, Skow D, Torcellini C, Tseng YC, Wang J, Wasti R, Werneburg B, Wu JP, Xiong Z. Goldberg DR, et al. Among authors: skow d. Bioorg Med Chem Lett. 2008 Feb 1;18(3):938-41. doi: 10.1016/j.bmcl.2007.12.037. Epub 2007 Dec 23. Bioorg Med Chem Lett. 2008. PMID: 18221871
31 results