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Discovery of ascomycin analogs with potent topical but weak systemic activity for treatment of inflammatory skin diseases.
Mollison KW, Fey TA, Gauvin DM, Sheets MP, Smith ML, Pong M, Krause R, Miller L, Or YS, Kawai M, Wagner R, Wiedeman PE, Clark RF, Gunawardana IW, Rhoades TA, Henry CL, Tu NP, BaMaung NY, Kopecka H, Liu L, Xie Q, Lane BC, Trevillyan JM, Marsh K, Luly JR, et al. Mollison KW, et al. Among authors: lane bc. Curr Pharm Des. 1998 Oct;4(5):367-79. Curr Pharm Des. 1998. PMID: 10197049 Review.
Rapamycin analogs with reduced systemic exposure.
Wagner R, Mollison KW, Liu L, Henry CL, Rosenberg TA, Bamaung N, Tu N, Wiedeman PE, Or Y, Luly JR, Lane BC, Trevillyan J, Chen YW, Fey T, Hsieh G, Marsh K, Nuss M, Jacobson PB, Wilcox D, Carlson RP, Carter GW, Djuric SW. Wagner R, et al. Among authors: lane bc. Bioorg Med Chem Lett. 2005 Dec 1;15(23):5340-3. doi: 10.1016/j.bmcl.2005.06.106. Epub 2005 Sep 26. Bioorg Med Chem Lett. 2005. PMID: 16185865
A macrolactam inhibitor of T helper type 1 and T helper type 2 cytokine biosynthesis for topical treatment of inflammatory skin diseases.
Mollison KW, Fey TA, Gauvin DM, Kolano RM, Sheets MP, Smith ML, Pong M, Nikolaidis NM, Lane BC, Trevillyan JM, Cannon J, Marsh K, Carter GW, Or YS, Chen YW, Hsieh GC, Luly JR. Mollison KW, et al. Among authors: lane bc. J Invest Dermatol. 1999 May;112(5):729-38. doi: 10.1046/j.1523-1747.1999.00567.x. J Invest Dermatol. 1999. PMID: 10233764 Free article.
44 results