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Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders.
Yoshida K, Taga T, Saito M, Suematsu S, Kumanogoh A, Tanaka T, Fujiwara H, Hirata M, Yamagami T, Nakahata T, Hirabayashi T, Yoneda Y, Tanaka K, Wang WZ, Mori C, Shiota K, Yoshida N, Kishimoto T. Yoshida K, et al. Among authors: yoshida n. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):407-11. doi: 10.1073/pnas.93.1.407. Proc Natl Acad Sci U S A. 1996. PMID: 8552649 Free PMC article.
Targeted disruption of the IL-6 related genes: gp130 and NF-IL-6.
Akira S, Yoshida K, Tanaka T, Taga T, Kishimoto T. Akira S, et al. Among authors: yoshida k. Immunol Rev. 1995 Dec;148:221-53. doi: 10.1111/j.1600-065x.1995.tb00100.x. Immunol Rev. 1995. PMID: 8825289 Review. No abstract available.
Osteoclasts are present in gp130-deficient mice.
Kawasaki K, Gao YH, Yokose S, Kaji Y, Nakamura T, Suda T, Yoshida K, Taga T, Kishimoto T, Kataoka H, Yuasa T, Norimatsu H, Yamaguchi A. Kawasaki K, et al. Among authors: yoshida k. Endocrinology. 1997 Nov;138(11):4959-65. doi: 10.1210/endo.138.11.5534. Endocrinology. 1997. PMID: 9348227
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