T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis.
Jayaraman T, Marks AR.
Jayaraman T, et al.
Mol Cell Biol. 1997 Jun;17(6):3005-12. doi: 10.1128/MCB.17.6.3005.
Mol Cell Biol. 1997.
PMID: 9154798
Free PMC article.
The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) calcium release channel is present on the endoplasmic reticulum of most cell types. T lymphocytes which have been made deficient in IP3R1 lack detectable IP3-induced intracellular calcium release and exhibit defectiv …
The type 1 inositol 1,4,5-trisphosphate receptor (IP3R1) calcium release channel is present on the endoplasmic reticulum of most cell types. …