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Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Vannini A, Volpari C, Filocamo G, Casavola EC, Brunetti M, Renzoni D, Chakravarty P, Paolini C, De Francesco R, Gallinari P, Steinkühler C, Di Marco S. Vannini A, et al. Among authors: paolini c. Proc Natl Acad Sci U S A. 2004 Oct 19;101(42):15064-9. doi: 10.1073/pnas.0404603101. Epub 2004 Oct 11. Proc Natl Acad Sci U S A. 2004. PMID: 15477595 Free PMC article.
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases.
Lahm A, Paolini C, Pallaoro M, Nardi MC, Jones P, Neddermann P, Sambucini S, Bottomley MJ, Lo Surdo P, Carfí A, Koch U, De Francesco R, Steinkühler C, Gallinari P. Lahm A, et al. Among authors: paolini c. Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17335-40. doi: 10.1073/pnas.0706487104. Epub 2007 Oct 23. Proc Natl Acad Sci U S A. 2007. PMID: 17956988 Free PMC article.
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells.
Rotili D, Tarantino D, Nebbioso A, Paolini C, Huidobro C, Lara E, Mellini P, Lenoci A, Pezzi R, Botta G, Lahtela-Kakkonen M, Poso A, Steinkühler C, Gallinari P, De Maria R, Fraga M, Esteller M, Altucci L, Mai A. Rotili D, et al. Among authors: paolini c. J Med Chem. 2012 Dec 27;55(24):10937-47. doi: 10.1021/jm3011614. Epub 2012 Dec 12. J Med Chem. 2012. PMID: 23189967
131 results