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(R,S)-4-phosphonophenylglycine, a potent and selective group III metabotropic glutamate receptor agonist, is anticonvulsive and neuroprotective in vivo.
Gasparini F, Bruno V, Battaglia G, Lukic S, Leonhardt T, Inderbitzin W, Laurie D, Sommer B, Varney MA, Hess SD, Johnson EC, Kuhn R, Urwyler S, Sauer D, Portet C, Schmutz M, Nicoletti F, Flor PJ. Gasparini F, et al. Among authors: kuhn r. J Pharmacol Exp Ther. 1999 Jun;289(3):1678-87. J Pharmacol Exp Ther. 1999. PMID: 10336568
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
Gasparini F, Lingenhöhl K, Stoehr N, Flor PJ, Heinrich M, Vranesic I, Biollaz M, Allgeier H, Heckendorn R, Urwyler S, Varney MA, Johnson EC, Hess SD, Rao SP, Sacaan AI, Santori EM, Veliçelebi G, Kuhn R. Gasparini F, et al. Among authors: kuhn r. Neuropharmacology. 1999 Oct;38(10):1493-503. doi: 10.1016/s0028-3908(99)00082-9. Neuropharmacology. 1999. PMID: 10530811
Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain.
Walker K, Bowes M, Panesar M, Davis A, Gentry C, Kesingland A, Gasparini F, Spooren W, Stoehr N, Pagano A, Flor PJ, Vranesic I, Lingenhoehl K, Johnson EC, Varney M, Urban L, Kuhn R. Walker K, et al. Among authors: kuhn r. Neuropharmacology. 2001;40(1):1-9. doi: 10.1016/s0028-3908(00)00113-1. Neuropharmacology. 2001. PMID: 11077065
Increased seizure susceptibility in mice lacking metabotropic glutamate receptor 7.
Sansig G, Bushell TJ, Clarke VR, Rozov A, Burnashev N, Portet C, Gasparini F, Schmutz M, Klebs K, Shigemoto R, Flor PJ, Kuhn R, Knoepfel T, Schroeder M, Hampson DR, Collett VJ, Zhang C, Duvoisin RM, Collingridge GL, van Der Putten H. Sansig G, et al. Among authors: kuhn r. J Neurosci. 2001 Nov 15;21(22):8734-45. doi: 10.1523/JNEUROSCI.21-22-08734.2001. J Neurosci. 2001. PMID: 11698585 Free PMC article.
1,424 results