Morishima H - Search Results

1

Synthesis and biological activities of topoisomerase I inhibitors, 6-N-amino analogues of NB-506.

Ohkubo M, Kojiri K, Kondo H, Tanaka S, Kawamoto H, Nishimura T, Nishimura I, Yoshinari T, Arakawa H, Suda H, Morishima H, Nishimura S. Ohkubo M, et al. Among authors: morishima h. Bioorg Med Chem Lett. 1999 May 3;9(9):1219-24. doi: 10.1016/s0960-894x(99)00188-2. Bioorg Med Chem Lett. 1999. PMID: 10340602

2

Mode of action of a new indolocarbazole anticancer agent, J-107088, targeting topoisomerase I.

Yoshinari T, Ohkubo M, Fukasawa K, Egashira S, Hara Y, Matsumoto M, Nakai K, Arakawa H, Morishima H, Nishimura S. Yoshinari T, et al. Among authors: morishima h. Cancer Res. 1999 Sep 1;59(17):4271-5. Cancer Res. 1999. PMID: 10485471

3

Synthesis and biological activities of NB-506 analogues: Effects of the positions of two hydroxyl groups at the indole rings.

Ohkubo M, Nishimura T, Honma T, Nishimura I, Ito S, Yoshinari T, Suda HA, Morishima H, Nishimura S. Ohkubo M, et al. Among authors: morishima h. Bioorg Med Chem Lett. 1999 Dec 6;9(23):3307-12. doi: 10.1016/s0960-894x(99)00595-8. Bioorg Med Chem Lett. 1999. PMID: 10612590

4

Synthesis and biological activities of NB-506 analogues modified at the glucose group.

Ohkubo M, Nishimura T, Kawamoto H, Nakano M, Honma T, Yoshinari T, Arakawa H, Suda H, Morishima H, Nishimura S. Ohkubo M, et al. Among authors: morishima h. Bioorg Med Chem Lett. 2000 Mar 6;10(5):419-22. doi: 10.1016/s0960-894x(00)00004-4. Bioorg Med Chem Lett. 2000. PMID: 10743939

5

A new class of type I protein geranylgeranyltransferase (GGTase I) inhibitor.

Sunami S, Ohkubo M, Sagara T, Ono J, Asahi S, Koito S, Morishima H. Sunami S, et al. Among authors: morishima h. Bioorg Med Chem Lett. 2002 Feb 25;12(4):629-32. doi: 10.1016/s0960-894x(01)00813-7. Bioorg Med Chem Lett. 2002. PMID: 11844687

6

Development of an orexin-2 receptor selective agonist, [Ala(11), D-Leu(15)]orexin-B.

Asahi S, Egashira S, Matsuda M, Iwaasa H, Kanatani A, Ohkubo M, Ihara M, Morishima H. Asahi S, et al. Among authors: morishima h. Bioorg Med Chem Lett. 2003 Jan 6;13(1):111-3. doi: 10.1016/s0960-894x(02)00851-x. Bioorg Med Chem Lett. 2003. PMID: 12467628

7

In vivo anti-tumor activity of a novel indolocarbazole compound, J-107088, on murine and human tumors transplanted into mice.

Arakawa H, Morita M, Kodera T, Okura A, Ohkubo M, Morishima H, Nishimura S. Arakawa H, et al. Among authors: morishima h. Jpn J Cancer Res. 1999 Oct;90(10):1163-70. doi: 10.1111/j.1349-7006.1999.tb00691.x. Jpn J Cancer Res. 1999. PMID: 10595746 Free PMC article.

8

Discovery of novel trans-3,5-disubstituted pyrrolidinylthio-1beta-methylcarbapenems.

Imamura H, Ohtake N, Shimizu A, Sato H, Sugimoto Y, Sakuraba S, Nagano R, Nakano M, Abe S, Suzuki-Sato C, Nishimura I, Kojima H, Tsuchiya Y, Yamada K, Hashizume T, Morishima H. Imamura H, et al. Among authors: morishima h. Bioorg Med Chem. 2000 Aug;8(8):1969-82. doi: 10.1016/s0968-0896(00)00125-5. Bioorg Med Chem. 2000. PMID: 11003142

9

A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues.

Honma T, Yoshizumi T, Hashimoto N, Hayashi K, Kawanishi N, Fukasawa K, Takaki T, Ikeura C, Ikuta M, Suzuki-Takahashi I, Hayama T, Nishimura S, Morishima H. Honma T, et al. Among authors: morishima h. J Med Chem. 2001 Dec 20;44(26):4628-40. doi: 10.1021/jm010326y. J Med Chem. 2001. PMID: 11741480

10

Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design.

Honma T, Hayashi K, Aoyama T, Hashimoto N, Machida T, Fukasawa K, Iwama T, Ikeura C, Ikuta M, Suzuki-Takahashi I, Iwasawa Y, Hayama T, Nishimura S, Morishima H. Honma T, et al. Among authors: morishima h. J Med Chem. 2001 Dec 20;44(26):4615-27. doi: 10.1021/jm0103256. J Med Chem. 2001. PMID: 11741479

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