Dunwiddie CT - Search Results

1

RPR120844, a novel, specific inhibitor of coagulation factor Xa inhibits venous thrombosis in the rabbit.

Bostwick JS, Bentley R, Morgan S, Brown K, Chu V, Ewing WR, Spada AP, Pauls H, Perrone MH, Dunwiddie CT, Leadley RJ Jr. Bostwick JS, et al. Among authors: dunwiddie ct. Thromb Haemost. 1999 Jan;81(1):157-60. Thromb Haemost. 1999. PMID: 10348709

2

Aminoisoquinolines: design and synthesis of an orally active benzamidine isostere for the inhibition of factor XA.

Choi-Sledeski YM, Becker MR, Green DM, Davis R, Ewing WR, Mason HJ, Ly C, Spada A, Liang G, Cheney D, Barton J, Chu V, Brown K, Colussi D, Bentley R, Leadley R, Dunwiddie C, Pauls HW. Choi-Sledeski YM, et al. Bioorg Med Chem Lett. 1999 Sep 6;9(17):2539-44. doi: 10.1016/s0960-894x(99)00421-7. Bioorg Med Chem Lett. 1999. PMID: 10498204

3

Comparison of enoxaparin, hirulog, and heparin as adjunctive antithrombotic therapy during thrombolysis with rtPA in the stenosed canine coronary artery.

Leadley RJ Jr, Kasiewski CJ, Bostwick JS, Bentley R, McVey MJ, White FJ, Perrone MH, Dunwiddie CT. Leadley RJ Jr, et al. Among authors: dunwiddie ct. Thromb Haemost. 1997 Oct;78(4):1278-85. Thromb Haemost. 1997. PMID: 9364998

4

Identification and initial structure-activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa.

Klein SI, Czekaj M, Gardner CJ, Guertin KR, Cheney DL, Spada AP, Bolton SA, Brown K, Colussi D, Heran CL, Morgan SR, Leadley RJ, Dunwiddie CT, Perrone MH, Chu V. Klein SI, et al. Among authors: dunwiddie ct. J Med Chem. 1998 Feb 12;41(4):437-50. doi: 10.1021/jm970482y. J Med Chem. 1998. PMID: 9484495

5

Inhibition of repetitive thrombus formation in the stenosed canine coronary artery by enoxaparin, but not by unfractionated heparin.

Leadley RJ Jr, Kasiewski CJ, Bostwick JS, Bentley R, Dunwiddie CT, Perrone MH. Leadley RJ Jr, et al. Among authors: dunwiddie ct. Arterioscler Thromb Vasc Biol. 1998 Jun;18(6):908-14. doi: 10.1161/01.atv.18.6.908. Arterioscler Thromb Vasc Biol. 1998. PMID: 9633930

6

Design and structure-activity relationships of potent and selective inhibitors of blood coagulation factor Xa.

Ewing WR, Becker MR, Manetta VE, Davis RS, Pauls HW, Mason H, Choi-Sledeski YM, Green D, Cha D, Spada AP, Cheney DL, Mason JS, Maignan S, Guilloteau JP, Brown K, Colussi D, Bentley R, Bostwick J, Kasiewski CJ, Morgan SR, Leadley RJ, Dunwiddie CT, Perrone MH, Chu V. Ewing WR, et al. Among authors: dunwiddie ct. J Med Chem. 1999 Sep 9;42(18):3557-71. doi: 10.1021/jm990040h. J Med Chem. 1999. PMID: 10479288

7

Sulfonamidopyrrolidinone factor Xa inhibitors: potency and selectivity enhancements via P-1 and P-4 optimization.

Choi-Sledeski YM, McGarry DG, Green DM, Mason HJ, Becker MR, Davis RS, Ewing WR, Dankulich WP, Manetta VE, Morris RL, Spada AP, Cheney DL, Brown KD, Colussi DJ, Chu V, Heran CL, Morgan SR, Bentley RG, Leadley RJ, Maignan S, Guilloteau JP, Dunwiddie CT, Pauls HW. Choi-Sledeski YM, et al. Among authors: dunwiddie ct. J Med Chem. 1999 Sep 9;42(18):3572-87. doi: 10.1021/jm990041+. J Med Chem. 1999. PMID: 10479289

8

Pharmacodynamic activity and antithrombotic efficacy of RPR120844, a novel inhibitor of coagulation factor Xa.

Leadley RJ Jr, Morgan SR, Bentley R, Bostwick JS, Kasiewski CJ, Heran C, Chu V, Brown K, Moxey P, Ewing WR, Pauls H, Spada AP, Perrone MH, Dunwiddie CT. Leadley RJ Jr, et al. Among authors: dunwiddie ct. J Cardiovasc Pharmacol. 1999 Dec;34(6):791-9. doi: 10.1097/00005344-199912000-00004. J Cardiovasc Pharmacol. 1999. PMID: 10598121

9

In vitro characterization of a novel factor Xa inhibitor, RPR 130737.

Chu V, Brown K, Colussi D, Choi YM, Green D, Pauls HW, Spada AP, Perrone MH, Leadley RJ Jr, Dunwiddie CT. Chu V, et al. Among authors: dunwiddie ct. Thromb Res. 2000 Jul 1;99(1):71-82. doi: 10.1016/s0049-3848(00)00227-9. Thromb Res. 2000. PMID: 11012377

10

Pharmacological characterization of a novel factor Xa inhibitor, FXV673.

Chu V, Brown K, Colussi D, Gao J, Bostwick J, Kasiewski C, Bentley R, Morgan S, Guertin K, Pauls HW, Gong Y, Zulli A, Perrone MH, Dunwiddie CT, Leadley RJ. Chu V, et al. Among authors: dunwiddie ct. Thromb Res. 2001 Aug 15;103(4):309-24. doi: 10.1016/s0049-3848(01)00328-0. Thromb Res. 2001. PMID: 11562341

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