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Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin.
Wu C, Ying H, Grinnell C, Bryant S, Miller R, Clabbers A, Bose S, McCarthy D, Zhu RR, Santora L, Davis-Taber R, Kunes Y, Fung E, Schwartz A, Sakorafas P, Gu J, Tarcsa E, Murtaza A, Ghayur T. Wu C, et al. Among authors: grinnell c. Nat Biotechnol. 2007 Nov;25(11):1290-7. doi: 10.1038/nbt1345. Epub 2007 Oct 14. Nat Biotechnol. 2007. PMID: 17934452
Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig.
Bardwell PD, Staron MM, Liu J, Tao Q, Scesney S, Bukofzer G, Rodriguez LE, Choi CH, Wang J, Chang Q, Dong F, Donawho C, Wang J, Grinnell CM, Tarcsa E, Hutchins C, Ghayur T, Gu J. Bardwell PD, et al. Among authors: grinnell cm. Protein Cell. 2018 Jan;9(1):121-129. doi: 10.1007/s13238-017-0429-z. Epub 2017 Jun 5. Protein Cell. 2018. PMID: 28585177 Free PMC article.
Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration.
Ding K, Eaton L, Bowley D, Rieser M, Chang Q, Harris MC, Clabbers A, Dong F, Shen J, Hackett SF, Touw DS, Bixby J, Zhong S, Benatuil L, Bose S, Grinnell C, Preston GM, Iyer R, Sadhukhan R, Marchie S, Overmeyer G, Ghayur T, van Riet DA, Tang S, Campochario PA, Gu J. Ding K, et al. Among authors: grinnell c. MAbs. 2017 Feb/Mar;9(2):269-284. doi: 10.1080/19420862.2016.1268305. MAbs. 2017. PMID: 27929753 Free PMC article.
Targeting Anti-TGF-β Therapy to Fibrotic Kidneys with a Dual Specificity Antibody Approach.
McGaraughty S, Davis-Taber RA, Zhu CZ, Cole TB, Nikkel AL, Chhaya M, Doyle KJ, Olson LM, Preston GM, Grinnell CM, Salte KM, Giamis AM, Luo Y, Sun V, Goodearl AD, Gopalakrishnan M, Lacy SE. McGaraughty S, et al. J Am Soc Nephrol. 2017 Dec;28(12):3616-3626. doi: 10.1681/ASN.2017010013. Epub 2017 Aug 21. J Am Soc Nephrol. 2017. PMID: 28827403 Free PMC article.
44 results