Aplin RT - Search Results

1

Mechanistic insights into the inhibition of serine proteases by monocyclic lactams.

Wilmouth RC, Kassamally S, Westwood NJ, Sheppard RJ, Claridge TD, Aplin RT, Wright PA, Pritchard GJ, Schofield CJ. Wilmouth RC, et al. Among authors: aplin rt. Biochemistry. 1999 Jun 22;38(25):7989-98. doi: 10.1021/bi990098y. Biochemistry. 1999. PMID: 10387042

2

Inhibition of TEM-2 beta-lactamase from Escherichia coli by clavulanic acid: observation of intermediates by electrospray ionization mass spectrometry.

Brown RP, Aplin RT, Schofield CJ. Brown RP, et al. Among authors: aplin rt. Biochemistry. 1996 Sep 24;35(38):12421-32. doi: 10.1021/bi961044g. Biochemistry. 1996. PMID: 8823177

3

Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase.

Wilmouth RC, Clifton IJ, Robinson CV, Roach PL, Aplin RT, Westwood NJ, Hajdu J, Schofield CJ. Wilmouth RC, et al. Among authors: aplin rt. Nat Struct Biol. 1997 Jun;4(6):456-62. doi: 10.1038/nsb0697-456. Nat Struct Biol. 1997. PMID: 9187653

4

Inhibition of elastase by N-sulfonylaryl beta-lactams: anatomy of a stable acyl-enzyme complex.

Wilmouth RC, Westwood NJ, Anderson K, Brownlee W, Claridge TD, Clifton IJ, Pritchard GJ, Aplin RT, Schofield CJ. Wilmouth RC, et al. Among authors: aplin rt. Biochemistry. 1998 Dec 15;37(50):17506-13. doi: 10.1021/bi9816249. Biochemistry. 1998. PMID: 9860865

5

Use of electrospray mass spectrometry to directly observe an acyl enzyme intermediate in beta-lactamase catalysis.

Aplin RT, Baldwin JE, Schofield CJ, Waley SG. Aplin RT, et al. FEBS Lett. 1990 Dec 17;277(1-2):212-4. doi: 10.1016/0014-5793(90)80847-c. FEBS Lett. 1990. PMID: 2269358 Free article.

6

L-delta-(alpha-Aminoadipoyl)-L-cysteinyl-D-valine synthetase: thioesterification of valine is not obligatory for peptide bond formation.

Shiau CY, Byford MF, Aplin RT, Baldwin JE, Schofield CJ. Shiau CY, et al. Among authors: aplin rt. Biochemistry. 1997 Jul 22;36(29):8798-806. doi: 10.1021/bi962932e. Biochemistry. 1997. PMID: 9220966

7

Investigations into the post-translational modification and mechanism of isopenicillin N:acyl-CoA acyltransferase using electrospray mass spectrometry.

Aplin RT, Baldwin JE, Roach PL, Robinson CV, Schofield CJ. Aplin RT, et al. Biochem J. 1993 Sep 1;294 ( Pt 2)(Pt 2):357-63. doi: 10.1042/bj2940357. Biochem J. 1993. PMID: 8396910 Free PMC article.

8

Mass spectrometric studies on the inhibition of TEM-2 beta-lactamase by clavulanic acid derivatives.

Brown RP, Aplin RT, Schofield CJ, Frydrych CH. Brown RP, et al. Among authors: aplin rt. J Antibiot (Tokyo). 1997 Feb;50(2):184-5. doi: 10.7164/antibiotics.50.184. J Antibiot (Tokyo). 1997. PMID: 9099233 Free article. No abstract available.

9

Molecular weight analysis of isopenicillin N synthase by electrospray mass spectrometry.

Aplin RT, Baldwin JE, Fujishima Y, Schofield CJ, Green BN, Jarvis SA. Aplin RT, et al. FEBS Lett. 1990 May 21;264(2):215-7. doi: 10.1016/0014-5793(90)80251-d. FEBS Lett. 1990. PMID: 2192915 Free article.

10

Disruption of dimerization and substrate phosphorylation inhibit factor inhibiting hypoxia-inducible factor (FIH) activity.

Lancaster DE, McNeill LA, McDonough MA, Aplin RT, Hewitson KS, Pugh CW, Ratcliffe PJ, Schofield CJ. Lancaster DE, et al. Among authors: aplin rt. Biochem J. 2004 Nov 1;383(Pt. 3):429-37. doi: 10.1042/BJ20040735. Biochem J. 2004. PMID: 15239670 Free PMC article.

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