Valente E - Search Results

1

Dipeptide derivatives of primaquine as transmission-blocking antimalarials: effect of aliphatic side-chain acylation on the gametocytocidal activity and on the formation of carboxyprimaquine in rat liver homogenates.

Portela MJ, Moreira R, Valente E, Constantino L, Iley J, Pinto J, Rosa R, Cravo P, do Rosário VE. Portela MJ, et al. Among authors: valente e. Pharm Res. 1999 Jun;16(6):949-55. doi: 10.1023/a:1018922425551. Pharm Res. 1999. PMID: 10397619

2

Kinetics and mechanism of hydrolysis of N-acyloxymethyl derivatives of azetidin-2-one.

Valente E, Gomes JR, Moreira R, Iley J. Valente E, et al. J Org Chem. 2004 May 14;69(10):3359-67. doi: 10.1021/jo0358123. J Org Chem. 2004. PMID: 15132543

3

Lipophilic pyrazinoic acid amide and ester prodrugs stability, activation and activity against M. tuberculosis.

Simões MF, Valente E, Gómez MJ, Anes E, Constantino L. Simões MF, et al. Among authors: valente e. Eur J Pharm Sci. 2009 Jun 28;37(3-4):257-63. doi: 10.1016/j.ejps.2009.02.012. Epub 2009 Mar 6. Eur J Pharm Sci. 2009. PMID: 19491013

4

Activation of benzoate model prodrugs by mycobacteria. Comparison with mammalian plasma and liver hydrolysis.

Valente E, Testa B, Constantino L. Valente E, et al. Eur J Pharm Sci. 2021 Jul 1;162:105831. doi: 10.1016/j.ejps.2021.105831. Epub 2021 Apr 9. Eur J Pharm Sci. 2021. PMID: 33839258 Free article.

5

Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors.

Clemente A, Domingos A, Grancho AP, Iley J, Moreira R, Neres J, Palma N, Santana AB, Valente E. Clemente A, et al. Among authors: valente e. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1065-8. doi: 10.1016/s0960-894x(01)00131-7. Bioorg Med Chem Lett. 2001. PMID: 11327591

6

Structure-activity relationships for dipeptide prodrugs of acyclovir: implications for prodrug design.

Santos CR, Capela R, Pereira CS, Valente E, Gouveia L, Pannecouque C, De Clercq E, Moreira R, Gomes P. Santos CR, et al. Among authors: valente e. Eur J Med Chem. 2009 Jun;44(6):2339-46. doi: 10.1016/j.ejmech.2008.08.009. Epub 2008 Sep 11. Eur J Med Chem. 2009. PMID: 18848738

7

Development of a method to investigate the hydrolysis of xenobiotic esters by a Mycobacterium smegmatis homogenate.

Valente E, Simões MF, Testa B, Constantino L. Valente E, et al. J Microbiol Methods. 2011 May;85(2):98-102. doi: 10.1016/j.mimet.2011.02.003. Epub 2011 Feb 16. J Microbiol Methods. 2011. PMID: 21335037

8

Esters of Pyrazinoic Acid Are Active against Pyrazinamide-Resistant Strains of Mycobacterium tuberculosis and Other Naturally Resistant Mycobacteria In Vitro and Ex Vivo within Macrophages.

Pires D, Valente E, Simões MF, Carmo N, Testa B, Constantino L, Anes E. Pires D, et al. Among authors: valente e. Antimicrob Agents Chemother. 2015 Dec;59(12):7693-9. doi: 10.1128/AAC.00936-15. Epub 2015 Oct 5. Antimicrob Agents Chemother. 2015. PMID: 26438493 Free PMC article.

In previous work, we have shown that POA esters and amides synthesized in our laboratory were stable in plasma (M. F. Simoes, E. Valente, M. J. Gomez, E. Anes, and L. Constantino, Eur J Pharm Sci 37:257-263, 2009, http://dx.doi.org/10.1016/j.ejps.2009.02.012) …

In previous work, we have shown that POA esters and amides synthesized in our laboratory were stable in plasma (M. F. Simoes, E. V …

9

Benzoic Acid Derivatives as Prodrugs for the Treatment of Tuberculosis.

Pais JP, Magalhães M, Antoniuk O, Barbosa I, Freire R, Pires D, Valente E, Testa B, Anes E, Constantino L. Pais JP, et al. Among authors: valente e. Pharmaceuticals (Basel). 2022 Sep 7;15(9):1118. doi: 10.3390/ph15091118. Pharmaceuticals (Basel). 2022. PMID: 36145340 Free PMC article.

10

Structure of warfarin in solution.

Valente EJ, Lingafelter EC, Porter WR, Trager WF. Valente EJ, et al. J Med Chem. 1977 Nov;20(11):1489-93. doi: 10.1021/jm00221a025. J Med Chem. 1977. PMID: 915911

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