Pavlovsky AG - Search Results

1

X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.

Pavlovsky AG, Williams MG, Ye QZ, Ortwine DF, Purchase CF 2nd, White AD, Dhanaraj V, Roth BD, Johnson LL, Hupe D, Humblet C, Blundell TL. Pavlovsky AG, et al. Protein Sci. 1999 Jul;8(7):1455-62. doi: 10.1110/ps.8.7.1455. Protein Sci. 1999. PMID: 10422833 Free PMC article.

2

Effect of species differences on stromelysin-1 (MMP-3) inhibitor potency. An explanation of inhibitor selectivity using homology modeling and chimeric proteins.

Johnson LL, Bornemeier DA, Janowicz JA, Chen J, Pavlovsky AG, Ortwine DF. Johnson LL, et al. Among authors: pavlovsky ag. J Biol Chem. 1999 Aug 27;274(35):24881-7. doi: 10.1074/jbc.274.35.24881. J Biol Chem. 1999. PMID: 10455161 Free article.

3

Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors.

O'Brien PM, Ortwine DF, Pavlovsky AG, Picard JA, Sliskovic DR, Roth BD, Dyer RD, Johnson LL, Man CF, Hallak H. O'Brien PM, et al. Among authors: pavlovsky ag. J Med Chem. 2000 Jan 27;43(2):156-66. doi: 10.1021/jm9903141. J Med Chem. 2000. PMID: 10649971

4

A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition.

Johnson LL, Pavlovsky AG, Johnson AR, Janowicz JA, Man CF, Ortwine DF, Purchase CF 2nd, White AD, Hupe DJ. Johnson LL, et al. Among authors: pavlovsky ag. J Biol Chem. 2000 Apr 14;275(15):11026-33. doi: 10.1074/jbc.275.15.11026. J Biol Chem. 2000. PMID: 10753905 Free article.

5

Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry.

Parker MH, Lunney EA, Ortwine DF, Pavlovsky AG, Humblet C, Brouillette CG. Parker MH, et al. Among authors: pavlovsky ag. Biochemistry. 1999 Oct 12;38(41):13592-601. doi: 10.1021/bi991222g. Biochemistry. 1999. PMID: 10521266

6

X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. Dhanaraj V, et al. Structure. 1996 Apr 15;4(4):375-86. doi: 10.1016/s0969-2126(96)00043-3. Structure. 1996. PMID: 8740360 Free article.

7

Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures.

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. Dhanaraj V, et al. Drug Des Discov. 1996 Apr;13(3-4):3-14. Drug Des Discov. 1996. PMID: 8874040

8

4-hydroxy-5,6-dihydropyrones. 2. Potent non-peptide inhibitors of HIV protease.

Tait BD, Hagen S, Domagala J, Ellsworth EL, Gajda C, Hamilton HW, Prasad JV, Ferguson D, Graham N, Hupe D, Nouhan C, Tummino PJ, Humblet C, Lunney EA, Pavlovsky A, Rubin J, Gracheck SJ, Baldwin ET, Bhat TN, Erickson JW, Gulnik SV, Liu B. Tait BD, et al. J Med Chem. 1997 Nov 7;40(23):3781-92. doi: 10.1021/jm970615f. J Med Chem. 1997. PMID: 9371244

9

Nonpeptidic HIV protease inhibitors possessing excellent antiviral activities and therapeutic indices. PD 178390: a lead HIV protease inhibitor.

Prasad JV, Boyer FE, Domagala JM, Ellsworth EL, Gajda C, Hamilton HW, Hagen SE, Markoski LJ, Steinbaugh BA, Tait BD, Humblet C, Lunney EA, Pavlovsky A, Rubin JR, Ferguson D, Graham N, Holler T, Hupe D, Nouhan C, Tummino PJ, Urumov A, Zeikus E, Zeikus G, Gracheck SJ, Erickson JW, et al. Prasad JV, et al. Bioorg Med Chem. 1999 Dec;7(12):2775-800. doi: 10.1016/s0968-0896(99)00215-1. Bioorg Med Chem. 1999. PMID: 10658583

10

Discovery and optimization of nonpeptide HIV-1 protease inhibitors.

Tummino PJ, Prasad JV, Ferguson D, Nouhan C, Graham N, Domagala JM, Ellsworth E, Gajda C, Hagen SE, Lunney EA, Para KS, Tait BD, Pavlovsky A, Erickson JW, Gracheck S, McQuade TJ, Hupe DJ. Tummino PJ, et al. Bioorg Med Chem. 1996 Sep;4(9):1401-10. doi: 10.1016/0968-0896(96)00134-4. Bioorg Med Chem. 1996. PMID: 8894098

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