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Page 1
Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.
Becker JW, Rotonda J, Soisson SM, Aspiotis R, Bayly C, Francoeur S, Gallant M, Garcia-Calvo M, Giroux A, Grimm E, Han Y, McKay D, Nicholson DW, Peterson E, Renaud J, Roy S, Thornberry N, Zamboni R. Becker JW, et al. J Med Chem. 2004 May 6;47(10):2466-74. doi: 10.1021/jm0305523. J Med Chem. 2004. PMID: 15115390
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis.
Rotonda J, Nicholson DW, Fazil KM, Gallant M, Gareau Y, Labelle M, Peterson EP, Rasper DM, Ruel R, Vaillancourt JP, Thornberry NA, Becker JW. Rotonda J, et al. Among authors: becker jw. Nat Struct Biol. 1996 Jul;3(7):619-25. doi: 10.1038/nsb0796-619. Nat Struct Biol. 1996. PMID: 8673606
Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.
Han Y, Giroux A, Grimm EL, Aspiotis R, Francoeur S, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt JP, Rasper DM, Tam J, Tawa P, Thornberry NA, Paterson EP, Garcia-Calvo M, Becker JW, Rotonda J, Nicholson DW, Zamboni RJ. Han Y, et al. Among authors: becker jw. Bioorg Med Chem Lett. 2004 Feb 9;14(3):805-8. doi: 10.1016/j.bmcl.2003.10.064. Bioorg Med Chem Lett. 2004. PMID: 14741294
Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.
Shi GQ, Dropinski JF, McKeever BM, Xu S, Becker JW, Berger JP, MacNaul KL, Elbrecht A, Zhou G, Doebber TW, Wang P, Chao YS, Forrest M, Heck JV, Moller DE, Jones AB. Shi GQ, et al. Among authors: becker jw. J Med Chem. 2005 Jun 30;48(13):4457-68. doi: 10.1021/jm0502135. J Med Chem. 2005. PMID: 15974597
Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.
Esser CK, Bugianesi RL, Caldwell CG, Chapman KT, Durette PL, Girotra NN, Kopka IE, Lanza TJ, Levorse DA, MacCoss M, Owens KA, Ponpipom MM, Simeone JP, Harrison RK, Niedzwiecki L, Becker JW, Marcy AI, Axel MG, Christen AJ, McDonnell J, Moore VL, Olszewski JM, Saphos C, Visco DM, Hagmann WK, et al. Esser CK, et al. Among authors: becker jw. J Med Chem. 1997 Mar 14;40(6):1026-40. doi: 10.1021/jm960465t. J Med Chem. 1997. PMID: 9083493
93 results