Ortwine DF - Search Results

1

Effect of species differences on stromelysin-1 (MMP-3) inhibitor potency. An explanation of inhibitor selectivity using homology modeling and chimeric proteins.

Johnson LL, Bornemeier DA, Janowicz JA, Chen J, Pavlovsky AG, Ortwine DF. Johnson LL, et al. Among authors: ortwine df. J Biol Chem. 1999 Aug 27;274(35):24881-7. doi: 10.1074/jbc.274.35.24881. J Biol Chem. 1999. PMID: 10455161 Free article.

2

X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.

Pavlovsky AG, Williams MG, Ye QZ, Ortwine DF, Purchase CF 2nd, White AD, Dhanaraj V, Roth BD, Johnson LL, Hupe D, Humblet C, Blundell TL. Pavlovsky AG, et al. Among authors: ortwine df. Protein Sci. 1999 Jul;8(7):1455-62. doi: 10.1110/ps.8.7.1455. Protein Sci. 1999. PMID: 10422833 Free PMC article.

3

Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors.

O'Brien PM, Ortwine DF, Pavlovsky AG, Picard JA, Sliskovic DR, Roth BD, Dyer RD, Johnson LL, Man CF, Hallak H. O'Brien PM, et al. Among authors: ortwine df. J Med Chem. 2000 Jan 27;43(2):156-66. doi: 10.1021/jm9903141. J Med Chem. 2000. PMID: 10649971

4

A rationalization of the acidic pH dependence for stromelysin-1 (Matrix metalloproteinase-3) catalysis and inhibition.

Johnson LL, Pavlovsky AG, Johnson AR, Janowicz JA, Man CF, Ortwine DF, Purchase CF 2nd, White AD, Hupe DJ. Johnson LL, et al. Among authors: ortwine df. J Biol Chem. 2000 Apr 14;275(15):11026-33. doi: 10.1074/jbc.275.15.11026. J Biol Chem. 2000. PMID: 10753905 Free article.

5

Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects.

Johnson AR, Pavlovsky AG, Ortwine DF, Prior F, Man CF, Bornemeier DA, Banotai CA, Mueller WT, McConnell P, Yan C, Baragi V, Lesch C, Roark WH, Wilson M, Datta K, Guzman R, Han HK, Dyer RD. Johnson AR, et al. Among authors: ortwine df. J Biol Chem. 2007 Sep 21;282(38):27781-91. doi: 10.1074/jbc.M703286200. Epub 2007 Jul 10. J Biol Chem. 2007. PMID: 17623656 Free article.

6

X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. Dhanaraj V, et al. Among authors: ortwine df. Structure. 1996 Apr 15;4(4):375-86. doi: 10.1016/s0969-2126(96)00043-3. Structure. 1996. PMID: 8740360 Free article.

7

Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry.

Parker MH, Lunney EA, Ortwine DF, Pavlovsky AG, Humblet C, Brouillette CG. Parker MH, et al. Among authors: ortwine df. Biochemistry. 1999 Oct 12;38(41):13592-601. doi: 10.1021/bi991222g. Biochemistry. 1999. PMID: 10521266

8

Designing inhibitors of the metalloproteinase superfamily: comparative analysis of representative structures.

Dhanaraj V, Ye QZ, Johnson LL, Hupe DJ, Ortwine DF, Dunbar JB Jr, Rubin JR, Pavlovsky A, Humblet C, Blundell TL. Dhanaraj V, et al. Among authors: ortwine df. Drug Des Discov. 1996 Apr;13(3-4):3-14. Drug Des Discov. 1996. PMID: 8874040

9

4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.

Spicer JA, Rewcastle GW, Kaufman MD, Black SL, Plummer MS, Denny WA, Quin J 3rd, Shahripour AB, Barrett SD, Whitehead CE, Milbank JB, Ohren JF, Gowan RC, Omer C, Camp HS, Esmaeil N, Moore K, Sebolt-Leopold JS, Pryzbranowski S, Merriman RL, Ortwine DF, Warmus JS, Flamme CM, Pavlovsky AG, Tecle H. Spicer JA, et al. Among authors: ortwine df. J Med Chem. 2007 Oct 18;50(21):5090-102. doi: 10.1021/jm0704548. Epub 2007 Sep 19. J Med Chem. 2007. PMID: 17880056

10

Synthesis of 1,4,7,8,9,10-hexahydro-9-methyl-6-nitropyrido[3,4-f]- quinoxaline-2,3-dione and related quinoxalinediones: characterization of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (and N-methyl-D-aspartate) receptor and anticonvulsant activity.

Bigge CF, Malone TC, Boxer PA, Nelson CB, Ortwine DF, Schelkun RM, Retz DM, Lescosky LJ, Borosky SA, Vartanian MG, et al. Bigge CF, et al. Among authors: ortwine df. J Med Chem. 1995 Sep 15;38(19):3720-40. doi: 10.1021/jm00019a003. J Med Chem. 1995. PMID: 7562904

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