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Niacin protects the isolated heart from ischemia-reperfusion injury.
Trueblood NA, Ramasamy R, Wang LF, Schaefer S. Trueblood NA, et al. Among authors: wang lf. Am J Physiol Heart Circ Physiol. 2000 Aug;279(2):H764-71. doi: 10.1152/ajpheart.2000.279.2.H764. Am J Physiol Heart Circ Physiol. 2000. PMID: 10924076 Free article.
Late sodium current inhibition alone with ranolazine is sufficient to reduce ischemia- and cardiac glycoside-induced calcium overload and contractile dysfunction mediated by reverse-mode sodium/calcium exchange.
Soliman D, Wang L, Hamming KS, Yang W, Fatehi M, Carter CC, Clanachan AS, Light PE. Soliman D, et al. Among authors: wang l. J Pharmacol Exp Ther. 2012 Nov;343(2):325-32. doi: 10.1124/jpet.112.196949. Epub 2012 Aug 9. J Pharmacol Exp Ther. 2012. PMID: 22879384
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