Engh RA - Search Results

1

Coagulation factor IXa: the relaxed conformation of Tyr99 blocks substrate binding.

Hopfner KP, Lang A, Karcher A, Sichler K, Kopetzki E, Brandstetter H, Huber R, Bode W, Engh RA. Hopfner KP, et al. Among authors: engh ra. Structure. 1999 Aug 15;7(8):989-96. doi: 10.1016/s0969-2126(99)80125-7. Structure. 1999. PMID: 10467148 Free article.

2

Enzyme flexibility, solvent and 'weak' interactions characterize thrombin-ligand interactions: implications for drug design.

Engh RA, Brandstetter H, Sucher G, Eichinger A, Baumann U, Bode W, Huber R, Poll T, Rudolph R, von der Saal W. Engh RA, et al. Structure. 1996 Nov 15;4(11):1353-62. doi: 10.1016/s0969-2126(96)00142-6. Structure. 1996. PMID: 8939759 Free article.

3

X-ray structure of active site-inhibited clotting factor Xa. Implications for drug design and substrate recognition.

Brandstetter H, Kühne A, Bode W, Huber R, von der Saal W, Wirthensohn K, Engh RA. Brandstetter H, et al. Among authors: engh ra. J Biol Chem. 1996 Nov 22;271(47):29988-92. doi: 10.1074/jbc.271.47.29988. J Biol Chem. 1996. PMID: 8939944 Free article.

4

Converting blood coagulation factor IXa into factor Xa: dramatic increase in amidolytic activity identifies important active site determinants.

Hopfner KP, Brandstetter H, Karcher A, Kopetzki E, Huber R, Engh RA, Bode W. Hopfner KP, et al. Among authors: engh ra. EMBO J. 1997 Nov 17;16(22):6626-35. doi: 10.1093/emboj/16.22.6626. EMBO J. 1997. PMID: 9362477 Free PMC article.

5

Staurosporine-induced conformational changes of cAMP-dependent protein kinase catalytic subunit explain inhibitory potential.

Prade L, Engh RA, Girod A, Kinzel V, Huber R, Bossemeyer D. Prade L, et al. Among authors: engh ra. Structure. 1997 Dec 15;5(12):1627-37. doi: 10.1016/s0969-2126(97)00310-9. Structure. 1997. PMID: 9438863 Free article.

6

New enzyme lineages by subdomain shuffling.

Hopfner KP, Kopetzki E, Kresse GB, Bode W, Huber R, Engh RA. Hopfner KP, et al. Among authors: engh ra. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9813-8. doi: 10.1073/pnas.95.17.9813. Proc Natl Acad Sci U S A. 1998. PMID: 9707558 Free PMC article.

7

The 1.8-A crystal structure of a matrix metalloproteinase 8-barbiturate inhibitor complex reveals a previously unobserved mechanism for collagenase substrate recognition.

Brandstetter H, Grams F, Glitz D, Lang A, Huber R, Bode W, Krell HW, Engh RA. Brandstetter H, et al. Among authors: engh ra. J Biol Chem. 2001 May 18;276(20):17405-12. doi: 10.1074/jbc.M007475200. Epub 2001 Jan 22. J Biol Chem. 2001. PMID: 11278347 Free article.

8

Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.

Breitenlechner C, Gassel M, Hidaka H, Kinzel V, Huber R, Engh RA, Bossemeyer D. Breitenlechner C, et al. Among authors: engh ra. Structure. 2003 Dec;11(12):1595-607. doi: 10.1016/j.str.2003.11.002. Structure. 2003. PMID: 14656443 Free article.

9

Structural basis for the regulation of insulin-like growth factors by IGF binding proteins.

Siwanowicz I, Popowicz GM, Wisniewska M, Huber R, Kuenkele KP, Lang K, Engh RA, Holak TA. Siwanowicz I, et al. Among authors: engh ra. Structure. 2005 Jan;13(1):155-67. doi: 10.1016/j.str.2004.11.009. Structure. 2005. PMID: 15642270 Free article.

10

Serpin structures.

Engh RA, Schulze AJ, Huber R, Bode W. Engh RA, et al. Behring Inst Mitt. 1993 Dec;(93):41-62. Behring Inst Mitt. 1993. PMID: 8172585 Review. No abstract available.

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