Boven E - Search Results

1

Novel anthracycline-spacer-beta-glucuronide,-beta-glucoside, and -beta-galactoside prodrugs for application in selective chemotherapy.

Leenders RG, Damen EW, Bijsterveld EJ, Scheeren HW, Houba PH, van der Meulen-Muileman IH, Boven E, Haisma HJ. Leenders RG, et al. Among authors: boven e. Bioorg Med Chem. 1999 Aug;7(8):1597-610. doi: 10.1016/s0968-0896(99)00095-4. Bioorg Med Chem. 1999. PMID: 10482452

2

Beta-glucuronidase-mediated drug release.

de Graaf M, Boven E, Scheeren HW, Haisma HJ, Pinedo HM. de Graaf M, et al. Among authors: boven e. Curr Pharm Des. 2002;8(15):1391-403. doi: 10.2174/1381612023394485. Curr Pharm Des. 2002. PMID: 12052215 Review.

3

Cytosolic beta-glycosidases for activation of glycoside prodrugs of daunorubicin.

de Graaf M, Pinedo HM, Quadir R, Haisma HJ, Boven E. de Graaf M, et al. Among authors: boven e. Biochem Pharmacol. 2003 Jun 1;65(11):1875-81. doi: 10.1016/s0006-2952(03)00183-7. Biochem Pharmacol. 2003. PMID: 12781339

4

A methylester of the glucuronide prodrug DOX-GA3 for improvement of tumor-selective chemotherapy.

de Graaf M, Nevalainen TJ, Scheeren HW, Pinedo HM, Haisma HJ, Boven E. de Graaf M, et al. Among authors: boven e. Biochem Pharmacol. 2004 Dec 1;68(11):2273-81. doi: 10.1016/j.bcp.2004.08.004. Biochem Pharmacol. 2004. PMID: 15498517

5

Comparison of two anthracycline-based prodrugs for activation by a monoclonal antibody-beta-glucuronidase conjugate in the specific treatment of cancer.

Haisma HJ, van Muijen M, Pinedo HM, Boven E. Haisma HJ, et al. Among authors: boven e. Cell Biophys. 1994;24-25:185-92. doi: 10.1007/BF02789229. Cell Biophys. 1994. PMID: 7736523

6

Characterization of novel anthracycline prodrugs activated by human beta-glucuronidase for use in antibody-directed enzyme prodrug therapy.

Houba PH, Leenders RG, Boven E, Scheeren JW, Pinedo HM, Haisma HJ. Houba PH, et al. Among authors: boven e. Biochem Pharmacol. 1996 Aug 9;52(3):455-63. doi: 10.1016/0006-2952(96)00248-1. Biochem Pharmacol. 1996. PMID: 8687500

7

The efficacy of the anthracycline prodrug daunorubicin-GA3 in human ovarian cancer xenografts.

Houba PH, Boven E, Erkelens CA, Leenders RG, Scheeren JW, Pinedo HM, Haisma HJ. Houba PH, et al. Among authors: boven e. Br J Cancer. 1998 Dec;78(12):1600-6. doi: 10.1038/bjc.1998.729. Br J Cancer. 1998. PMID: 9862570 Free PMC article.

8

A novel doxorubicin-glucuronide prodrug DOX-GA3 for tumour-selective chemotherapy: distribution and efficacy in experimental human ovarian cancer.

Houba PH, Boven E, van der Meulen-Muileman IH, Leenders RG, Scheeren JW, Pinedo HM, Haisma HJ. Houba PH, et al. Among authors: boven e. Br J Cancer. 2001 Feb;84(4):550-7. doi: 10.1054/bjoc.2000.1640. Br J Cancer. 2001. PMID: 11207053 Free PMC article.

9

Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.

Houba PH, Boven E, van der Meulen-Muileman IH, Leenders RG, Scheeren JW, Pinedo HM, Haisma HJ. Houba PH, et al. Among authors: boven e. Int J Cancer. 2001 Feb 15;91(4):550-4. doi: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1075>3.0.co;2-l. Int J Cancer. 2001. PMID: 11251980

10

A monoclonal antibody-beta-glucuronidase conjugate as activator of the prodrug epirubicin-glucuronide for specific treatment of cancer.

Haisma HJ, Boven E, van Muijen M, de Jong J, van der Vijgh WJ, Pinedo HM. Haisma HJ, et al. Among authors: boven e. Br J Cancer. 1992 Sep;66(3):474-8. doi: 10.1038/bjc.1992.298. Br J Cancer. 1992. PMID: 1520585 Free PMC article.

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