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Structural characterization of the interactions of optimized product inhibitors with the N-terminal proteinase domain of the hepatitis C virus (HCV) NS3 protein by NMR and modelling studies.
Cicero DO, Barbato G, Koch U, Ingallinella P, Bianchi E, Nardi MC, Steinkühler C, Cortese R, Matassa V, De Francesco R, Pessi A, Bazzo R. Cicero DO, et al. Among authors: ingallinella p. J Mol Biol. 1999 Jun 4;289(2):385-96. doi: 10.1006/jmbi.1999.2746. J Mol Biol. 1999. PMID: 10366512
Optimization of the P'-region of peptide inhibitors of hepatitis C virus NS3/4A protease.
Ingallinella P, Bianchi E, Ingenito R, Koch U, Steinkühler C, Altamura S, Pessi A. Ingallinella P, et al. Biochemistry. 2000 Oct 24;39(42):12898-906. doi: 10.1021/bi001590g. Biochemistry. 2000. PMID: 11041854
Binding was sequentially increased by introduction of the previously optimized P-region [Ingallinella et al. (1998) Biochemistry 37, 8906-8914], change of the P4' residue, and combinatorial optimization of positions P2'-P3'. ...
Binding was sequentially increased by introduction of the previously optimized P-region [Ingallinella et al. (1998) Biochemist …
29 results