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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B. Herreman A, et al. Among authors: van leuven f. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7. doi: 10.1073/pnas.96.21.11872. Proc Natl Acad Sci U S A. 1999. PMID: 10518543 Free PMC article.
Production of intracellular amyloid-containing fragments in hippocampal neurons expressing human amyloid precursor protein and protection against amyloidogenesis by subtle amino acid substitutions in the rodent sequence.
De Strooper B, Simons M, Multhaup G, Van Leuven F, Beyreuther K, Dotti CG. De Strooper B, et al. Among authors: van leuven f. EMBO J. 1995 Oct 16;14(20):4932-8. doi: 10.1002/j.1460-2075.1995.tb00176.x. EMBO J. 1995. PMID: 7588622 Free PMC article.
Exchanging the extracellular domain of amyloid precursor protein for horseradish peroxidase does not interfere with alpha-secretase cleavage of the beta-amyloid region, but randomizes secretion in Madin-Darby canine kidney cells.
De Strooper B, Craessaerts K, Van Leuven F, Van Den Berghe H. De Strooper B, et al. Among authors: van leuven f, van den berghe h. J Biol Chem. 1995 Dec 22;270(51):30310-4. doi: 10.1074/jbc.270.51.30310. J Biol Chem. 1995. PMID: 8530453 Free article.
Basolateral secretion of amyloid precursor protein in Madin-Darby canine kidney cells is disturbed by alterations of intracellular pH and by introducing a mutation associated with familial Alzheimer's disease.
De Strooper B, Craessaerts K, Dewachter I, Moechars D, Greenberg B, Van Leuven F, Van den Berghe H. De Strooper B, et al. Among authors: van leuven f, van den berghe h. J Biol Chem. 1995 Feb 24;270(8):4058-65. doi: 10.1074/jbc.270.8.4058. J Biol Chem. 1995. PMID: 7876155 Free article.
341 results