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Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.
Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR. Sun Y, et al. Circ Res. 2009 Feb 27;104(4):455-65. doi: 10.1161/CIRCRESAHA.108.182568. Epub 2009 Jan 2. Circ Res. 2009. PMID: 19122179 Free PMC article.
Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.
Li S, Sun Y, Liang CP, Thorp EB, Han S, Jehle AW, Saraswathi V, Pridgen B, Kanter JE, Li R, Welch CL, Hasty AH, Bornfeldt KE, Breslow JL, Tabas I, Tall AR. Li S, et al. Among authors: sun y. Circ Res. 2009 Nov 20;105(11):1072-82. doi: 10.1161/CIRCRESAHA.109.199570. Epub 2009 Oct 15. Circ Res. 2009. PMID: 19834009 Free PMC article.
Spontaneous atherothrombosis and medial degradation in Apoe-/-, Npc1-/- mice.
Welch CL, Sun Y, Arey BJ, Lemaitre V, Sharma N, Ishibashi M, Sayers S, Li R, Gorelik A, Pleskac N, Collins-Fletcher K, Yasuda Y, Bromme D, D'Armiento JM, Ogletree ML, Tall AR. Welch CL, et al. Among authors: sun y. Circulation. 2007 Nov 20;116(21):2444-52. doi: 10.1161/CIRCULATIONAHA.107.701276. Epub 2007 Nov 5. Circulation. 2007. PMID: 17984379
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