Hollfelder F - Search Results

1

Impaired transition state complementarity in the hydrolysis of O-arylphosphorothioates by protein-tyrosine phosphatases.

Zhang YL, Hollfelder F, Gordon SJ, Chen L, Keng YF, Wu L, Herschlag D, Zhang ZY. Zhang YL, et al. Among authors: hollfelder f. Biochemistry. 1999 Sep 14;38(37):12111-23. doi: 10.1021/bi990836i. Biochemistry. 1999. PMID: 10508416

2

The nature of the transition state for enzyme-catalyzed phosphoryl transfer. Hydrolysis of O-aryl phosphorothioates by alkaline phosphatase.

Hollfelder F, Herschlag D. Hollfelder F, et al. Biochemistry. 1995 Sep 26;34(38):12255-64. doi: 10.1021/bi00038a021. Biochemistry. 1995. PMID: 7547968

3

Transition-State Interactions in a Promiscuous Enzyme: Sulfate and Phosphate Monoester Hydrolysis by Pseudomonas aeruginosa Arylsulfatase.

van Loo B, Berry R, Boonyuen U, Mohamed MF, Golicnik M, Hengge AC, Hollfelder F. van Loo B, et al. Among authors: hollfelder f. Biochemistry. 2019 Mar 12;58(10):1363-1378. doi: 10.1021/acs.biochem.8b00996. Epub 2019 Feb 27. Biochemistry. 2019. PMID: 30810299 Free PMC article.

4

A Trojan horse transition state analogue generated by MgF3- formation in an enzyme active site.

Baxter NJ, Olguin LF, Golicnik M, Feng G, Hounslow AM, Bermel W, Blackburn GM, Hollfelder F, Waltho JP, Williams NH. Baxter NJ, et al. Among authors: hollfelder f. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14732-7. doi: 10.1073/pnas.0604448103. Epub 2006 Sep 21. Proc Natl Acad Sci U S A. 2006. PMID: 16990434 Free PMC article.

5

Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes.

Baxter NJ, Blackburn GM, Marston JP, Hounslow AM, Cliff MJ, Bermel W, Williams NH, Hollfelder F, Wemmer DE, Waltho JP. Baxter NJ, et al. Among authors: hollfelder f. J Am Chem Soc. 2008 Mar 26;130(12):3952-8. doi: 10.1021/ja078000n. Epub 2008 Mar 5. J Am Chem Soc. 2008. PMID: 18318536

6

Specificity Effects of Amino Acid Substitutions in Promiscuous Hydrolases: Context-Dependence of Catalytic Residue Contributions to Local Fitness Landscapes in Nearby Sequence Space.

Bayer CD, van Loo B, Hollfelder F. Bayer CD, et al. Among authors: hollfelder f. Chembiochem. 2017 Jun 1;18(11):1001-1015. doi: 10.1002/cbic.201600657. Epub 2017 May 2. Chembiochem. 2017. PMID: 28464395 Free PMC article.

7

Structural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester.

van Loo B, Schober M, Valkov E, Heberlein M, Bornberg-Bauer E, Faber K, Hyvönen M, Hollfelder F. van Loo B, et al. Among authors: hollfelder f. J Mol Biol. 2018 Mar 30;430(7):1004-1023. doi: 10.1016/j.jmb.2018.02.010. Epub 2018 Feb 17. J Mol Biol. 2018. PMID: 29458126 Free PMC article.

8

Efficient, crosswise catalytic promiscuity among enzymes that catalyze phosphoryl transfer.

Mohamed MF, Hollfelder F. Mohamed MF, et al. Among authors: hollfelder f. Biochim Biophys Acta. 2013 Jan;1834(1):417-24. doi: 10.1016/j.bbapap.2012.07.015. Epub 2012 Aug 3. Biochim Biophys Acta. 2013. PMID: 22885024 Review.

9

Picoliter cell lysate assays in microfluidic droplet compartments for directed enzyme evolution.

Kintses B, Hein C, Mohamed MF, Fischlechner M, Courtois F, Lainé C, Hollfelder F. Kintses B, et al. Among authors: hollfelder f. Chem Biol. 2012 Aug 24;19(8):1001-9. doi: 10.1016/j.chembiol.2012.06.009. Chem Biol. 2012. PMID: 22921067

10

High-Throughput, Lysis-Free Screening for Sulfatase Activity Using Escherichia coli Autodisplay in Microdroplets.

van Loo B, Heberlein M, Mair P, Zinchenko A, Schüürmann J, Eenink BDG, Holstein JM, Dilkaute C, Jose J, Hollfelder F, Bornberg-Bauer E. van Loo B, et al. Among authors: hollfelder f. ACS Synth Biol. 2019 Dec 20;8(12):2690-2700. doi: 10.1021/acssynbio.9b00274. Epub 2019 Dec 4. ACS Synth Biol. 2019. PMID: 31738524

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