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5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.
Ostrowski T, Wroblowski B, Busson R, Rozenski J, De Clercq E, Bennett MS, Champness JN, Summers WC, Sanderson MR, Herdewijn P. Ostrowski T, et al. Among authors: sanderson mr. J Med Chem. 1998 Oct 22;41(22):4343-53. doi: 10.1021/jm980287z. J Med Chem. 1998. PMID: 9784109
Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
Bennett MS, Wien F, Champness JN, Batuwangala T, Rutherford T, Summers WC, Sun H, Wright G, Sanderson MR. Bennett MS, et al. Among authors: sanderson mr. FEBS Lett. 1999 Jan 25;443(2):121-5. doi: 10.1016/s0014-5793(98)01619-6. FEBS Lett. 1999. PMID: 9989588 Free article.
174 results