MacFarlane WM - Search Results

1

Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.

MacFarlane WM, Chapman JC, Shepherd RM, Hashmi MN, Kamimura N, Cosgrove KE, O'Brien RE, Barnes PD, Hart AW, Docherty HM, Lindley KJ, Aynsley-Green A, James RF, Docherty K, Dunne MJ. MacFarlane WM, et al. J Biol Chem. 1999 Nov 26;274(48):34059-66. doi: 10.1074/jbc.274.48.34059. J Biol Chem. 1999. PMID: 10567373 Free article.

2

The p38/reactivating kinase mitogen-activated protein kinase cascade mediates the activation of the transcription factor insulin upstream factor 1 and insulin gene transcription by high glucose in pancreatic beta-cells.

Macfarlane WM, Smith SB, James RF, Clifton AD, Doza YN, Cohen P, Docherty K. Macfarlane WM, et al. J Biol Chem. 1997 Aug 15;272(33):20936-44. doi: 10.1074/jbc.272.33.20936. J Biol Chem. 1997. PMID: 9252422 Free article.

3

Impaired expression of transcription factor IUF1 in a pancreatic beta-cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis).

Macfarlane WM, Cragg H, Docherty HM, Read ML, James RF, Aynsley-Green A, Docherty K. Macfarlane WM, et al. FEBS Lett. 1997 Aug 18;413(2):304-8. doi: 10.1016/s0014-5793(97)00874-0. FEBS Lett. 1997. PMID: 9280302 Free article.

4

Glucose stimulates translocation of the homeodomain transcription factor PDX1 from the cytoplasm to the nucleus in pancreatic beta-cells.

Macfarlane WM, McKinnon CM, Felton-Edkins ZA, Cragg H, James RF, Docherty K. Macfarlane WM, et al. J Biol Chem. 1999 Jan 8;274(2):1011-6. doi: 10.1074/jbc.274.2.1011. J Biol Chem. 1999. PMID: 9873045 Free article.

5

Glucose regulates islet amyloid polypeptide gene transcription in a PDX1- and calcium-dependent manner.

Macfarlane WM, Campbell SC, Elrick LJ, Oates V, Bermano G, Lindley KJ, Aynsley-Green A, Dunne MJ, James RF, Docherty K. Macfarlane WM, et al. J Biol Chem. 2000 May 19;275(20):15330-5. doi: 10.1074/jbc.M908045199. J Biol Chem. 2000. PMID: 10748090 Free article.

6

Glucose modulation of insulin mRNA levels is dependent on transcription factor PDX-1 and occurs independently of changes in intracellular Ca2+.

Macfarlane WM, Shepherd RM, Cosgrove KE, James RF, Dunne MJ, Docherty K. Macfarlane WM, et al. Diabetes. 2000 Mar;49(3):418-23. doi: 10.2337/diabetes.49.3.418. Diabetes. 2000. PMID: 10868963

7

IUF1, a nutrient responsive transcription factor in the pancreatic beta-cells.

Macfarlane WM, Docherty K. Macfarlane WM, et al. Biochem Soc Trans. 1996 May;24(2):239S. doi: 10.1042/bst024239s. Biochem Soc Trans. 1996. PMID: 8736897 No abstract available.

8

Insulin stimulates pancreatic-duodenal homoeobox factor-1 (PDX1) DNA-binding activity and insulin promoter activity in pancreatic beta cells.

Wu H, MacFarlane WM, Tadayyon M, Arch JR, James RF, Docherty K. Wu H, et al. Among authors: macfarlane wm. Biochem J. 1999 Dec 15;344 Pt 3(Pt 3):813-8. Biochem J. 1999. PMID: 10585868 Free PMC article.

9

Persistent hyperinsulinaemic hyperglycaemia of infancy-derived cells; implications for beta-cells that replicate in vitro.

Dunne MJ, Shepherd RM, Cosgrove KE, Macfarlane WM, Lindley KJ, James RF, Aynsley-Green A. Dunne MJ, et al. Among authors: macfarlane wm. J Mol Endocrinol. 2000 Jun;24(3):313-20. doi: 10.1677/jme.0.0240313. J Mol Endocrinol. 2000. PMID: 10828824 Review. No abstract available.

10

Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.

Macfarlane WM, O'Brien RE, Barnes PD, Shepherd RM, Cosgrove KE, Lindley KJ, Aynsley-Green A, James RF, Docherty K, Dunne MJ. Macfarlane WM, et al. Diabetes. 2000 Jun;49(6):953-60. doi: 10.2337/diabetes.49.6.953. Diabetes. 2000. PMID: 10866047

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