Casper MD - Search Results

1

Structure-activity relationships of novel 2-substituted quinazoline antibacterial agents.

Kung PP, Casper MD, Cook KL, Wilson-Lingardo L, Risen LM, Vickers TA, Ranken R, Blyn LB, Wyatt JR, Cook PD, Ecker DJ. Kung PP, et al. Among authors: casper md. J Med Chem. 1999 Nov 4;42(22):4705-13. doi: 10.1021/jm9903500. J Med Chem. 1999. PMID: 10579832

2

Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets.

Kawasaki AM, Casper MD, Freier SM, Lesnik EA, Zounes MC, Cummins LL, Gonzalez C, Cook PD. Kawasaki AM, et al. Among authors: casper md. J Med Chem. 1993 Apr 2;36(7):831-41. doi: 10.1021/jm00059a007. J Med Chem. 1993. PMID: 8464037

3

Discovery and structure-activity relationship of 3-methoxy-N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide (APD791): a highly selective 5-hydroxytryptamine2A receptor inverse agonist for the treatment of arterial thrombosis.

Xiong Y, Teegarden BR, Choi JS, Strah-Pleynet S, Decaire M, Jayakumar H, Dosa PI, Casper MD, Pham L, Feichtinger K, Ullman B, Adams J, Yuskin D, Frazer J, Morgan M, Sadeque A, Chen W, Webb RR, Connolly DT, Semple G, Al-Shamma H. Xiong Y, et al. Among authors: casper md. J Med Chem. 2010 Jun 10;53(11):4412-21. doi: 10.1021/jm100044a. J Med Chem. 2010. PMID: 20455563

4

Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: in vitro profiling and in vivo evaluation.

Semple G, Tran TA, Kramer B, Hsu D, Han S, Choi J, Vallar P, Casper MD, Zou N, Hauser EK, Thomsen W, Whelan K, Sengupta D, Morgan M, Sekiguchi Y, Kanuma K, Chaki S, Grottick AJ. Semple G, et al. Among authors: casper md. Bioorg Med Chem Lett. 2009 Nov 1;19(21):6166-71. doi: 10.1016/j.bmcl.2009.09.003. Epub 2009 Sep 6. Bioorg Med Chem Lett. 2009. PMID: 19773162

5

Solubilized phenyl-pyrazole ureas as potent, selective 5-HT(2A) inverse-agonists and their application as antiplatelet agents.

Dosa PI, Strah-Pleynet S, Jayakumar H, Casper M, Decaire M, Xiong Y, Lehmann J, Choi K, Elwell K, Wong A, Webb RR, Adams JW, Ramirez J, Richman JG, Thomsen W, Semple G, Teegarden BR. Dosa PI, et al. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5486-9. doi: 10.1016/j.bmcl.2009.07.073. Epub 2009 Jul 18. Bioorg Med Chem Lett. 2009. PMID: 19665894

6

Discovery of 4-(dimethylamino)quinazolines as potent and selective antagonists for the melanin-concentrating hormone receptor 1.

Kanuma K, Omodera K, Nishiguchi M, Funakoshi T, Chaki S, Semple G, Tran TA, Kramer B, Hsu D, Casper M, Thomsen B, Beeley N, Sekiguchi Y. Kanuma K, et al. Bioorg Med Chem Lett. 2005 May 16;15(10):2565-9. doi: 10.1016/j.bmcl.2005.03.052. Bioorg Med Chem Lett. 2005. PMID: 15863317

7

Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1.

Kanuma K, Omodera K, Nishiguchi M, Funakoshi T, Chaki S, Semple G, Tran TA, Kramer B, Hsu D, Casper M, Thomsen B, Sekiguchi Y. Kanuma K, et al. Bioorg Med Chem Lett. 2005 Sep 1;15(17):3853-6. doi: 10.1016/j.bmcl.2005.05.121. Bioorg Med Chem Lett. 2005. PMID: 16002290

8

Allyl group as a protecting group for internucleotide phosphate and thiophosphate linkages in oligonucleotide synthesis: facile oxidation and deprotection conditions.

Manoharan M, Lu Y, Casper MD, Just G. Manoharan M, et al. Among authors: casper md. Org Lett. 2000 Feb 10;2(3):243-6. doi: 10.1021/ol9910518. Org Lett. 2000. PMID: 10814292

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