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Potent, orally active GPIIb/IIIa antagonists containing a nipecotic acid subunit. Structure-activity studies leading to the discovery of RWJ-53308.
Hoekstra WJ, Maryanoff BE, Damiano BP, Andrade-Gordon P, Cohen JH, Costanzo MJ, Haertlein BJ, Hecker LR, Hulshizer BL, Kauffman JA, Keane P, McComsey DF, Mitchell JA, Scott L, Shah RD, Yabut SC. Hoekstra WJ, et al. Among authors: shah rd. J Med Chem. 1999 Dec 16;42(25):5254-65. doi: 10.1021/jm990418b. J Med Chem. 1999. PMID: 10602710
Hydrazinonaphthalene and azonaphthalene thrombopoietin mimics are nonpeptidyl promoters of megakaryocytopoiesis.
Duffy KJ, Darcy MG, Delorme E, Dillon SB, Eppley DF, Erickson-Miller C, Giampa L, Hopson CB, Huang Y, Keenan RM, Lamb P, Leong L, Liu N, Miller SG, Price AT, Rosen J, Shah R, Shaw TN, Smith H, Stark KC, Tian SS, Tyree C, Wiggall KJ, Zhang L, Luengo JI. Duffy KJ, et al. J Med Chem. 2001 Oct 25;44(22):3730-45. doi: 10.1021/jm010283l. J Med Chem. 2001. PMID: 11606138
Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men.
Wu PY, Van Scoyk M, McHale SS, Chou CF, Riddick G, Farouq K, Hu B, Kraskauskiene V, Koblinski J, Lyons C, Rijal A, Vudatha V, Zhang D, Trevino JG, Shah RD, Nana-Sinkam P, Huang Y, Ma SF, Noth I, Hughes-Halbert C, Seewaldt VL, Chen CY, Winn RA. Wu PY, et al. Among authors: shah rd. iScience. 2024 Jan 11;27(2):108858. doi: 10.1016/j.isci.2024.108858. eCollection 2024 Feb 16. iScience. 2024. PMID: 38303720 Free PMC article.
169 results