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A novel peroxisome proliferator-activated receptor alpha/gamma dual agonist demonstrates favorable effects on lipid homeostasis.
Guo Q, Sahoo SP, Wang PR, Milot DP, Ippolito MC, Wu MS, Baffic J, Biswas C, Hernandez M, Lam MH, Sharma N, Han W, Kelly LJ, MacNaul KL, Zhou G, Desai R, Heck JV, Doebber TW, Berger JP, Moller DE, Sparrow CP, Chao YS, Wright SD. Guo Q, et al. Among authors: berger jp. Endocrinology. 2004 Apr;145(4):1640-8. doi: 10.1210/en.2003-1270. Epub 2003 Dec 30. Endocrinology. 2004. PMID: 14701675
Design and synthesis of potent and subtype-selective PPARalpha agonists.
Desai RC, Metzger E, Santini C, Meinke PT, Heck JV, Berger JP, MacNaul KL, Cai TQ, Wright SD, Agrawal A, Moller DE, Sahoo SP. Desai RC, et al. Bioorg Med Chem Lett. 2006 Mar 15;16(6):1673-8. doi: 10.1016/j.bmcl.2005.12.022. Epub 2005 Dec 27. Bioorg Med Chem Lett. 2006. PMID: 16384704
Differential gene regulation in human versus rodent hepatocytes by peroxisome proliferator-activated receptor (PPAR) alpha. PPAR alpha fails to induce peroxisome proliferation-associated genes in human cells independently of the level of receptor expresson.
Lawrence JW, Li Y, Chen S, DeLuca JG, Berger JP, Umbenhauer DR, Moller DE, Zhou G. Lawrence JW, et al. Among authors: berger jp. J Biol Chem. 2001 Aug 24;276(34):31521-7. doi: 10.1074/jbc.M103306200. Epub 2001 Jun 19. J Biol Chem. 2001. PMID: 11418601 Free article.
Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.
Berger J, Leibowitz MD, Doebber TW, Elbrecht A, Zhang B, Zhou G, Biswas C, Cullinan CA, Hayes NS, Li Y, Tanen M, Ventre J, Wu MS, Berger GD, Mosley R, Marquis R, Santini C, Sahoo SP, Tolman RL, Smith RG, Moller DE. Berger J, et al. Among authors: berger gd. J Biol Chem. 1999 Mar 5;274(10):6718-25. doi: 10.1074/jbc.274.10.6718. J Biol Chem. 1999. PMID: 10037770 Free article.
4,084 results