Hamilton A - Search Results

1

Prenyltransferase inhibitors block superoxide production by pulmonary vascular smooth muscle.

Boota A, Johnson B, Lee KL, Blaskovich MA, Liu SX, Kagan VE, Hamilton A, Pitt B, Sebti SM, Davies P. Boota A, et al. Among authors: hamilton a. Am J Physiol Lung Cell Mol Physiol. 2000 Feb;278(2):L329-34. doi: 10.1152/ajplung.2000.278.2.L329. Am J Physiol Lung Cell Mol Physiol. 2000. PMID: 10666117 Free article.

2

Signal transduction pathways of IL-1beta-mediated iNOS in pulmonary vascular smooth muscle cells.

Finder JD, Petrus JL, Hamilton A, Villavicencio RT, Pitt BR, Sebti SM. Finder JD, et al. Among authors: hamilton a. Am J Physiol Lung Cell Mol Physiol. 2001 Oct;281(4):L816-23. doi: 10.1152/ajplung.2001.281.4.L816. Am J Physiol Lung Cell Mol Physiol. 2001. PMID: 11557585 Free article.

3

Rational design of Ras prenyltransferase inhibitors as potential anticancer drugs.

Sebti SM, Hamilton AD. Sebti SM, et al. Among authors: hamilton ad. Biochem Soc Trans. 1996 Aug;24(3):692-9. doi: 10.1042/bst0240692. Biochem Soc Trans. 1996. PMID: 8878828 Review. No abstract available.

4

Inhibition of protein geranylgeranylation causes a superinduction of nitric-oxide synthase-2 by interleukin-1beta in vascular smooth muscle cells.

Finder JD, Litz JL, Blaskovich MA, McGuire TF, Qian Y, Hamilton AD, Davies P, Sebti SM. Finder JD, et al. Among authors: hamilton ad. J Biol Chem. 1997 May 23;272(21):13484-8. doi: 10.1074/jbc.272.21.13484. J Biol Chem. 1997. PMID: 9153192 Free article.

5

Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.

Stark WW Jr, Blaskovich MA, Johnson BA, Qian Y, Vasudevan A, Pitt B, Hamilton AD, Sebti SM, Davies P. Stark WW Jr, et al. Among authors: hamilton ad. Am J Physiol. 1998 Jul;275(1):L55-63. doi: 10.1152/ajplung.1998.275.1.L55. Am J Physiol. 1998. PMID: 9688935

6

Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor.

Lerner EC, Qian Y, Hamilton AD, Sebti SM. Lerner EC, et al. Among authors: hamilton ad. J Biol Chem. 1995 Nov 10;270(45):26770-3. doi: 10.1074/jbc.270.45.26770. J Biol Chem. 1995. PMID: 7592913 Free article.

7

Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes.

Lerner EC, Qian Y, Blaskovich MA, Fossum RD, Vogt A, Sun J, Cox AD, Der CJ, Hamilton AD, Sebti SM. Lerner EC, et al. Among authors: hamilton ad. J Biol Chem. 1995 Nov 10;270(45):26802-6. doi: 10.1074/jbc.270.45.26802. J Biol Chem. 1995. PMID: 7592920 Free article.

8

CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase.

McGuire TF, Qian Y, Blaskovich MA, Fossum RD, Sun J, Marlowe T, Corey SJ, Wathen SP, Vogt A, Hamilton AD, et al. McGuire TF, et al. Among authors: hamilton ad. Biochem Biophys Res Commun. 1995 Sep 5;214(1):295-303. doi: 10.1006/bbrc.1995.2287. Biochem Biophys Res Commun. 1995. PMID: 7669049

9

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

Sun J, Qian Y, Hamilton AD, Sebti SM. Sun J, et al. Among authors: hamilton ad. Cancer Res. 1995 Oct 1;55(19):4243-7. Cancer Res. 1995. PMID: 7671229

10

A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing.

Vogt A, Qian Y, Blaskovich MA, Fossum RD, Hamilton AD, Sebti SM. Vogt A, et al. Among authors: hamilton ad. J Biol Chem. 1995 Jan 13;270(2):660-4. doi: 10.1074/jbc.270.2.660. J Biol Chem. 1995. PMID: 7822292 Free article.

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