De Francesco R - Search Results

1

Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease.

Narjes F, Brunetti M, Colarusso S, Gerlach B, Koch U, Biasiol G, Fattori D, De Francesco R, Matassa VG, Steinkühler C. Narjes F, et al. Among authors: de francesco r. Biochemistry. 2000 Feb 22;39(7):1849-61. doi: 10.1021/bi9924260. Biochemistry. 2000. PMID: 10677236

2

A designed P1 cysteine mimetic for covalent and non-covalent inhibitors of HCV NS3 protease.

Narjes F, Koehler KF, Koch U, Gerlach B, Colarusso S, Steinkühler C, Brunetti M, Altamura S, De Francesco R, Matassa VG. Narjes F, et al. Among authors: de francesco r. Bioorg Med Chem Lett. 2002 Feb 25;12(4):701-4. doi: 10.1016/s0960-894x(01)00842-3. Bioorg Med Chem Lett. 2002. PMID: 11844705

3

A scintillation proximity active site binding assay for the hepatitis C virus serine protease.

Steinkühler C, Biasiol G, Cerretani M, Di Renzo L, Brunetti M, Ingallinella P, De Francesco R, Altamura S. Steinkühler C, et al. Among authors: de francesco r. Anal Biochem. 2002 Aug 1;307(1):99-104. doi: 10.1016/s0003-2697(02)00013-1. Anal Biochem. 2002. PMID: 12137785

4

Phenethyl amides as novel noncovalent inhibitors of hepatitis C virus NS3/4A protease: discovery, initial SAR, and molecular modeling.

Colarusso S, Koch U, Gerlach B, Steinkühler C, De Francesco R, Altamura S, Matassa VG, Narjes F. Colarusso S, et al. Among authors: de francesco r. J Med Chem. 2003 Jan 30;46(3):345-8. doi: 10.1021/jm025594q. J Med Chem. 2003. PMID: 12540231

5

In vitro selection and characterization of hepatitis C virus serine protease variants resistant to an active-site peptide inhibitor.

Trozzi C, Bartholomew L, Ceccacci A, Biasiol G, Pacini L, Altamura S, Narjes F, Muraglia E, Paonessa G, Koch U, De Francesco R, Steinkuhler C, Migliaccio G. Trozzi C, et al. Among authors: de francesco r. J Virol. 2003 Mar;77(6):3669-79. doi: 10.1128/jvi.77.6.3669-3679.2003. J Virol. 2003. PMID: 12610142 Free PMC article.

6

Discovery of alpha,gamma-diketo acids as potent selective and reversible inhibitors of hepatitis C virus NS5b RNA-dependent RNA polymerase.

Summa V, Petrocchi A, Pace P, Matassa VG, De Francesco R, Altamura S, Tomei L, Koch U, Neuner P. Summa V, et al. Among authors: de francesco r. J Med Chem. 2004 Jan 1;47(1):14-7. doi: 10.1021/jm0342109. J Med Chem. 2004. PMID: 14695815

7

2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis.

Koch U, Attenni B, Malancona S, Colarusso S, Conte I, Di Filippo M, Harper S, Pacini B, Giomini C, Thomas S, Incitti I, Tomei L, De Francesco R, Altamura S, Matassa VG, Narjes F. Koch U, et al. Among authors: de francesco r. J Med Chem. 2006 Mar 9;49(5):1693-705. doi: 10.1021/jm051064t. J Med Chem. 2006. PMID: 16509585

8

In vitro activity of hepatitis C virus protease NS3 purified from recombinant Baculovirus-infected Sf9 cells.

Steinkühler C, Tomei L, De Francesco R. Steinkühler C, et al. Among authors: de francesco r. J Biol Chem. 1996 Mar 15;271(11):6367-73. doi: 10.1074/jbc.271.11.6367. J Biol Chem. 1996. PMID: 8626434 Free article.

9

Synthetic depsipeptide substrates for the assay of human hepatitis C virus protease.

Bianchi E, Steinkühler C, Taliani M, Urbani A, De Francesco R, Pessi A. Bianchi E, et al. Among authors: de francesco r. Anal Biochem. 1996 Jun 1;237(2):239-44. doi: 10.1006/abio.1996.0235. Anal Biochem. 1996. PMID: 8660572

10

Activity of purified hepatitis C virus protease NS3 on peptide substrates.

Steinkühler C, Urbani A, Tomei L, Biasiol G, Sardana M, Bianchi E, Pessi A, De Francesco R. Steinkühler C, et al. Among authors: de francesco r. J Virol. 1996 Oct;70(10):6694-700. doi: 10.1128/JVI.70.10.6694-6700.1996. J Virol. 1996. PMID: 8794305 Free PMC article.

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