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Brain-derived neurotrophic factor bound with lecithin derivative showed a markedly enhanced pharmacological potency due to its potent cell membrane affinity followed by prolonged MAPK activation.
Igarashi R, Nakayama T, Takenaga M, Ichinohe M, Yamaguchi Y, Matsumoto K, Kitagawa A, Nakamura N, Kawai S, Nakagawa T, Taiji M, Nakayama C, Mizushima Y. Igarashi R, et al. Among authors: takenaga m. J Control Release. 2005 Feb 2;102(2):463-73. doi: 10.1016/j.jconrel.2004.10.027. J Control Release. 2005. PMID: 15653164
Lecithinization of IL-6 enhances its thrombopoietic activity in mice.
Igarashi R, Tsutsumi Y, Fujii H, Tsunoda S, Ochiai A, Takenaga M, Morizawa Y, Mayumi T, Mizushima Y. Igarashi R, et al. Among authors: takenaga m. J Pharm Pharmacol. 1997 Jan;49(1):113-8. doi: 10.1111/j.2042-7158.1997.tb06763.x. J Pharm Pharmacol. 1997. PMID: 9120762
114 results