Peng H - Search Results

1

Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase.

Peng H, Xie W, Kim DI, Zalkow LH, Powis G, Otterness DM, Abraham RT. Peng H, et al. Bioorg Med Chem. 2000 Feb;8(2):299-306. doi: 10.1016/s0968-0896(99)00284-9. Bioorg Med Chem. 2000. PMID: 10722152

Their potency ranged from 1.1 to > 100 microM; the best ones compare very favorably with that of the novel cyano-containing 5,6-seco-cholesteryl acid 1 (IC50=2.2microM) reported by us recently (Peng, H.; Zalkow, L. H.; Abraham, R. T.; Powis, G. J. Med. Che …

Their potency ranged from 1.1 to > 100 microM; the best ones compare very favorably with that of the novel cyano-containing 5,6-seco-chol …

2

Novel pyrrolo-quinoline derivatives as potent inhibitors for PI3-kinase related kinases.

Peng H, Kim DI, Sarkaria JN, Cho YS, Abraham RT, Zalkow LH. Peng H, et al. Bioorg Med Chem. 2002 Jan;10(1):167-74. doi: 10.1016/s0968-0896(01)00260-7. Bioorg Med Chem. 2002. PMID: 11738618

3

Synthesis and MEK1 inhibitory activities of imido-substituted 2-chloro-1,4-naphthoquinones.

Bakare O, Ashendel CL, Peng H, Zalkow LH, Burgess EM. Bakare O, et al. Among authors: peng h. Bioorg Med Chem. 2003 Jul 17;11(14):3165-70. doi: 10.1016/s0968-0896(03)00267-0. Bioorg Med Chem. 2003. PMID: 12818679

4

Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel.

Peng H, Zalkow LH, Abraham RT, Powis G. Peng H, et al. J Med Chem. 1998 Nov 19;41(24):4677-80. doi: 10.1021/jm980500r. J Med Chem. 1998. PMID: 9822537 No abstract available.

5

3Beta-hydroxy-6-aza-cholestane and related analogues as phosphatidylinositol specific phospholipase C (PI-PLC) inhibitors with antitumor activity.

Xie W, Peng H, Zalkow LH, Li YH, Zhu C, Powis G, Kunkel M. Xie W, et al. Among authors: peng h. Bioorg Med Chem. 2000 Apr;8(4):699-706. doi: 10.1016/s0968-0896(00)00014-6. Bioorg Med Chem. 2000. PMID: 10819158

6

Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase.

Peng H, Xie W, Otterness DM, Cogswell JP, McConnell RT, Carter HL, Powis G, Abraham RT, Zalkow LH. Peng H, et al. J Med Chem. 2001 Mar 1;44(5):834-48. doi: 10.1021/jm0004401. J Med Chem. 2001. PMID: 11262093

7

Structure-activity relationship of aza-steroids as PI-PLC inhibitors.

Xie W, Peng H, Kim DI, Kunkel M, Powis G, Zalkow LH. Xie W, et al. Among authors: peng h. Bioorg Med Chem. 2001 May;9(5):1073-83. doi: 10.1016/s0968-0896(00)00302-3. Bioorg Med Chem. 2001. PMID: 11377165

8

Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-alpha-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel.

Peng H, Zalkow LH, Abraham RT, Powis G. Peng H, et al. J Med Chem. 1999 May 6;42(9):1682. doi: 10.1021/jm990020f. J Med Chem. 1999. PMID: 10229637 No abstract available.

9

Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach.

Xin Z, Peng H, Zhang A, Talreja T, Kumaravel G, Xu L, Rohde E, Jung MY, Shackett MN, Kocisko D, Chollate S, Dunah AW, Snodgrass-Belt PA, Arnold HM, Taveras AG, Rhodes KJ, Scannevin RH. Xin Z, et al. Among authors: peng h. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7277-80. doi: 10.1016/j.bmcl.2011.10.047. Epub 2011 Oct 19. Bioorg Med Chem Lett. 2011. PMID: 22061640

10

Novel bicyclic piperazine derivatives of triazolotriazine and triazolopyrimidines as highly potent and selective adenosine A2A receptor antagonists.

Peng H, Kumaravel G, Yao G, Sha L, Wang J, Van Vlijmen H, Bohnert T, Huang C, Vu CB, Ensinger CL, Chang H, Engber TM, Whalley ET, Petter RC. Peng H, et al. J Med Chem. 2004 Dec 2;47(25):6218-29. doi: 10.1021/jm0494321. J Med Chem. 2004. PMID: 15566292

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