Powis G - Search Results

1

Steroidal derived acids as inhibitors of human Cdc25A protein phosphatase.

Peng H, Xie W, Kim DI, Zalkow LH, Powis G, Otterness DM, Abraham RT. Peng H, et al. Among authors: powis g. Bioorg Med Chem. 2000 Feb;8(2):299-306. doi: 10.1016/s0968-0896(99)00284-9. Bioorg Med Chem. 2000. PMID: 10722152

Their potency ranged from 1.1 to > 100 microM; the best ones compare very favorably with that of the novel cyano-containing 5,6-seco-cholesteryl acid 1 (IC50=2.2microM) reported by us recently (Peng, H.; Zalkow, L. H.; Abraham, R. T.; Powis, G. J. Med. Chem. 1998 …

Their potency ranged from 1.1 to > 100 microM; the best ones compare very favorably with that of the novel cyano-containing 5,6-seco-chol …

2

Novel CDC25A phosphatase inhibitors from pyrolysis of 3-alpha-azido-B-homo-6-oxa-4-cholesten-7-one on silica gel.

Peng H, Zalkow LH, Abraham RT, Powis G. Peng H, et al. Among authors: powis g. J Med Chem. 1998 Nov 19;41(24):4677-80. doi: 10.1021/jm980500r. J Med Chem. 1998. PMID: 9822537 No abstract available.

3

3Beta-hydroxy-6-aza-cholestane and related analogues as phosphatidylinositol specific phospholipase C (PI-PLC) inhibitors with antitumor activity.

Xie W, Peng H, Zalkow LH, Li YH, Zhu C, Powis G, Kunkel M. Xie W, et al. Among authors: powis g. Bioorg Med Chem. 2000 Apr;8(4):699-706. doi: 10.1016/s0968-0896(00)00014-6. Bioorg Med Chem. 2000. PMID: 10819158

4

Syntheses and biological activities of a novel group of steroidal derived inhibitors for human Cdc25A protein phosphatase.

Peng H, Xie W, Otterness DM, Cogswell JP, McConnell RT, Carter HL, Powis G, Abraham RT, Zalkow LH. Peng H, et al. Among authors: powis g. J Med Chem. 2001 Mar 1;44(5):834-48. doi: 10.1021/jm0004401. J Med Chem. 2001. PMID: 11262093

5

Structure-activity relationship of aza-steroids as PI-PLC inhibitors.

Xie W, Peng H, Kim DI, Kunkel M, Powis G, Zalkow LH. Xie W, et al. Among authors: powis g. Bioorg Med Chem. 2001 May;9(5):1073-83. doi: 10.1016/s0968-0896(00)00302-3. Bioorg Med Chem. 2001. PMID: 11377165

6

Semisynthetic pyrrolizidine alkaloid N-oxide antitumor agents. Esters of heliotridine.

Zalkow LH, Glinski JA, Gelbaum LT, Moore D, Melder D, Powis G. Zalkow LH, et al. Among authors: powis g. J Med Chem. 1988 Aug;31(8):1520-6. doi: 10.1021/jm00403a008. J Med Chem. 1988. PMID: 3397989

7

Novel CDC25A Phosphatase Inhibitors from Pyrolysis of 3-alpha-Azido-B-homo-6-oxa-4-cholesten-7-one on Silica Gel.

Peng H, Zalkow LH, Abraham RT, Powis G. Peng H, et al. Among authors: powis g. J Med Chem. 1999 May 6;42(9):1682. doi: 10.1021/jm990020f. J Med Chem. 1999. PMID: 10229637 No abstract available.

8

Inhibition of protein tyrosine phosphatase by the antitumor agent gallium nitrate.

Berggren MM, Burns LA, Abraham RT, Powis G. Berggren MM, et al. Among authors: powis g. Cancer Res. 1993 Apr 15;53(8):1862-6. Cancer Res. 1993. PMID: 8467506

9

Macrocyclic pyrrolizidine alkaloids from Senecio anonymus. Separation of a complex alkaloid extract using droplet counter-current chromatography.

Zalkow LH, Asibal CF, Glinski JA, Bonetti SJ, Gelbaum LT, VanDerveer D, Powis G. Zalkow LH, et al. Among authors: powis g. J Nat Prod. 1988 Jul-Aug;51(4):690-702. doi: 10.1021/np50058a005. J Nat Prod. 1988. PMID: 3210016

10

Preferential inhibition of the platelet-derived growth factor receptor tyrosine kinase by staurosporine.

Secrist JP, Sehgal I, Powis G, Abraham RT. Secrist JP, et al. Among authors: powis g. J Biol Chem. 1990 Nov 25;265(33):20394-400. J Biol Chem. 1990. PMID: 2173705 Free article.

In a previous study, we demonstrated that staurosporine, a known inhibitor of protein kinase C, blocked PDGF-induced [Ca2+]i increases in Swiss mouse 3T3 fibroblasts by a mechanism that appeared unrelated to inhibition of protein kinase activity (Olsen, R., Melder, D., Seewald, M …

In a previous study, we demonstrated that staurosporine, a known inhibitor of protein kinase C, blocked PDGF-induced [Ca2+]i increases in Sw …

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