Minnikin DE - Search Results

1

Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis.

Kremer L, Douglas JD, Baulard AR, Morehouse C, Guy MR, Alland D, Dover LG, Lakey JH, Jacobs WR Jr, Brennan PJ, Minnikin DE, Besra GS. Kremer L, et al. Among authors: minnikin de. J Biol Chem. 2000 Jun 2;275(22):16857-64. doi: 10.1074/jbc.M000569200. J Biol Chem. 2000. PMID: 10747933 Free article.

2

Analogues of thiolactomycin: potential drugs with enhanced anti-mycobacterial activity.

Douglas JD, Senior SJ, Morehouse C, Phetsukiri B, Campbell IB, Besra GS, Minnikin DE. Douglas JD, et al. Among authors: minnikin de. Microbiology (Reading). 2002 Oct;148(Pt 10):3101-3109. doi: 10.1099/00221287-148-10-3101. Microbiology (Reading). 2002. PMID: 12368443 Free article.

3

Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis.

Kremer L, Dover LG, Carrère S, Nampoothiri KM, Lesjean S, Brown AK, Brennan PJ, Minnikin DE, Locht C, Besra GS. Kremer L, et al. Among authors: minnikin de. Biochem J. 2002 Jun 1;364(Pt 2):423-30. doi: 10.1042/BJ20011628. Biochem J. 2002. PMID: 12023885 Free PMC article.

4

Biochemical characterization of acyl carrier protein (AcpM) and malonyl-CoA:AcpM transacylase (mtFabD), two major components of Mycobacterium tuberculosis fatty acid synthase II.

Kremer L, Nampoothiri KM, Lesjean S, Dover LG, Graham S, Betts J, Brennan PJ, Minnikin DE, Locht C, Besra GS. Kremer L, et al. Among authors: minnikin de. J Biol Chem. 2001 Jul 27;276(30):27967-74. doi: 10.1074/jbc.M103687200. Epub 2001 May 23. J Biol Chem. 2001. PMID: 11373295 Free article.

5

Biphenyl-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS. Senior SJ, et al. Among authors: minnikin de. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3685-8. doi: 10.1016/j.bmcl.2003.08.015. Bioorg Med Chem Lett. 2003. PMID: 14552758

6

Acetylene-based analogues of thiolactomycin, active against Mycobacterium tuberculosis mtFabH fatty acid condensing enzyme.

Senior SJ, Illarionov PA, Gurcha SS, Campbell IB, Schaeffer ML, Minnikin DE, Besra GS. Senior SJ, et al. Among authors: minnikin de. Bioorg Med Chem Lett. 2004 Jan 19;14(2):373-6. doi: 10.1016/j.bmcl.2003.10.061. Bioorg Med Chem Lett. 2004. PMID: 14698162

7

Synthesis and properties of methyl 5-(1'R,2'S)-(2-octadecylcycloprop-1-yl)pentanoate and other omega-19 chiral cyclopropane fatty acids and esters related to mycobacterial mycolic acids.

Coxon GD, Al Dulayymi JR, Morehouse C, Brennan PJ, Besra GS, Baird MS, Minnikin DE. Coxon GD, et al. Among authors: minnikin de. Chem Phys Lipids. 2004 Jan;127(1):35-46. doi: 10.1016/j.chemphyslip.2003.09.001. Chem Phys Lipids. 2004. PMID: 14706739

8

The methyl-branched fortifications of Mycobacterium tuberculosis.

Minnikin DE, Kremer L, Dover LG, Besra GS. Minnikin DE, et al. Chem Biol. 2002 May;9(5):545-53. doi: 10.1016/s1074-5521(02)00142-4. Chem Biol. 2002. PMID: 12031661 Review.

9

Synthesis of methyl (Z)-tetracos-5-enoate and both enantiomers of ethyl (E)-6-methyltetracos-4-enoate: possible intermediates in the biosynthesis of mycolic acids in mycobacteria.

Besra GS, Minnikin DE, Wheeler PR, Ratledge C. Besra GS, et al. Among authors: minnikin de. Chem Phys Lipids. 1993 Nov;66(1-2):23-34. doi: 10.1016/0009-3084(93)90027-z. Chem Phys Lipids. 1993. PMID: 8118916

10

Antimycobacterial activities of isoxyl and new derivatives through the inhibition of mycolic acid synthesis.

Phetsuksiri B, Baulard AR, Cooper AM, Minnikin DE, Douglas JD, Besra GS, Brennan PJ. Phetsuksiri B, et al. Among authors: minnikin de. Antimicrob Agents Chemother. 1999 May;43(5):1042-51. doi: 10.1128/AAC.43.5.1042. Antimicrob Agents Chemother. 1999. PMID: 10223912 Free PMC article.

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