Berkhout TA - Search Results

1

The role of fractalkine in the recruitment of monocytes to the endothelium.

Chapman GA, Moores KE, Gohil J, Berkhout TA, Patel L, Green P, Macphee CH, Stewart BR. Chapman GA, et al. Among authors: berkhout ta. Eur J Pharmacol. 2000 Mar 31;392(3):189-95. doi: 10.1016/s0014-2999(00)00117-5. Eur J Pharmacol. 2000. PMID: 10762673

2

Selective binding of the truncated form of the chemokine CKbeta8 (25-99) to CC chemokine receptor 1(CCR1).

Berkhout TA, Gohil J, Gonzalez P, Nicols CL, Moores KE, Macphee CH, White JR, Groot PH. Berkhout TA, et al. Biochem Pharmacol. 2000 Mar 1;59(5):591-6. doi: 10.1016/s0006-2952(99)00354-8. Biochem Pharmacol. 2000. PMID: 10660125

3

Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity.

Ludwig A, Berkhout T, Moores K, Groot P, Chapman G. Ludwig A, et al. J Immunol. 2002 Jan 15;168(2):604-12. doi: 10.4049/jimmunol.168.2.604. J Immunol. 2002. PMID: 11777952

4

Identification of a truncated form of the CC chemokine CK beta-8 demonstrating greatly enhanced biological activity.

Macphee CH, Appelbaum ER, Johanson K, Moores KE, Imburgia CS, Fornwald J, Berkhout T, Brawner M, Groot PH, O'Donnell K, O'Shannessy D, Scott G, White JR. Macphee CH, et al. J Immunol. 1998 Dec 1;161(11):6273-9. J Immunol. 1998. PMID: 9834116

5

Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B.

Berkhout TA, Sarau HM, Moores K, White JR, Elshourbagy N, Appelbaum E, Reape RJ, Brawner M, Makwana J, Foley JJ, Schmidt DB, Imburgia C, McNulty D, Matthews J, O'Donnell K, O'Shannessy D, Scott M, Groot PH, Macphee C. Berkhout TA, et al. J Biol Chem. 1997 Jun 27;272(26):16404-13. doi: 10.1074/jbc.272.26.16404. J Biol Chem. 1997. PMID: 9195948 Free article.

6

CCR2B receptor antagonists: conversion of a weak HTS hit to a potent lead compound.

Forbes IT, Cooper DG, Dodds EK, Hickey DM, Ife RJ, Meeson M, Stockley M, Berkhout TA, Gohil J, Groot PH, Moores K. Forbes IT, et al. Among authors: berkhout ta. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1803-6. doi: 10.1016/s0960-894x(00)00347-4. Bioorg Med Chem Lett. 2000. PMID: 10969972

7

CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach.

Berkhout TA, Blaney FE, Bridges AM, Cooper DG, Forbes IT, Gribble AD, Groot PH, Hardy A, Ife RJ, Kaur R, Moores KE, Shillito H, Willetts J, Witherington J. Berkhout TA, et al. J Med Chem. 2003 Sep 11;46(19):4070-86. doi: 10.1021/jm030862l. J Med Chem. 2003. PMID: 12954060

8

Conformationally restricted indolopiperidine derivatives as potent CCR2B receptor antagonists.

Witherington J, Bordas V, Cooper DG, Forbes IT, Gribble AD, Ife RJ, Berkhout T, Gohil J, Groot PH. Witherington J, et al. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2177-80. doi: 10.1016/s0960-894x(01)00397-3. Bioorg Med Chem Lett. 2001. PMID: 11514164

9

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A. Hundhausen C, et al. Among authors: berkhout ta. Blood. 2003 Aug 15;102(4):1186-95. doi: 10.1182/blood-2002-12-3775. Epub 2003 Apr 24. Blood. 2003. PMID: 12714508 Free article.

10

Separation of immunomodulatory and cholesterol-lowering activities of heterocyclic azaspiranes.

Albrightson CR, Bugelski PJ, Berkhout TA, Jackson B, Kerns WD, Organ AJ, Badger AM. Albrightson CR, et al. Among authors: berkhout ta. J Pharmacol Exp Ther. 1995 Feb;272(2):689-98. J Pharmacol Exp Ther. 1995. PMID: 7853183

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