Wang QC - Search Results

1

Cytotoxic activity of disulfide-stabilized recombinant immunotoxin RFB4(dsFv)-PE38 (BL22) toward fresh malignant cells from patients with B-cell leukemias.

Kreitman RJ, Margulies I, Stetler-Stevenson M, Wang QC, FitzGerald DJ, Pastan I. Kreitman RJ, et al. Among authors: wang qc. Clin Cancer Res. 2000 Apr;6(4):1476-87. Clin Cancer Res. 2000. PMID: 10778980

2

Lowering the isoelectric point of the Fv portion of recombinant immunotoxins leads to decreased nonspecific animal toxicity without affecting antitumor activity.

Onda M, Nagata S, Tsutsumi Y, Vincent JJ, Wang Q, Kreitman RJ, Lee B, Pastan I. Onda M, et al. Cancer Res. 2001 Jul 1;61(13):5070-7. Cancer Res. 2001. PMID: 11431343

3

Antitumor activity and pharmacokinetics in mice of a recombinant immunotoxin containing a disulfide-stabilized Fv fragment.

Reiter Y, Pai LH, Brinkmann U, Wang QC, Pastan I. Reiter Y, et al. Among authors: wang qc. Cancer Res. 1994 May 15;54(10):2714-8. Cancer Res. 1994. PMID: 8168102

4

Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.

Wang QC, Pai LH, Debinski W, FitzGerald DJ, Pastan I. Wang QC, et al. Cancer Res. 1993 Oct 1;53(19):4588-94. Cancer Res. 1993. PMID: 8402632

5

Complete regression of human B-cell lymphoma xenografts in mice treated with recombinant anti-CD22 immunotoxin RFB4(dsFv)-PE38 at doses tolerated by cynomolgus monkeys.

Kreitman RJ, Wang QC, FitzGerald DJ, Pastan I. Kreitman RJ, et al. Among authors: wang qc. Int J Cancer. 1999 Mar 31;81(1):148-55. doi: 10.1002/(sici)1097-0215(19990331)81:1<148::aid-ijc24>3.0.co;2-l. Int J Cancer. 1999. PMID: 10077166

6

Anti-tumor activity of K1-LysPE38QQR, an immunotoxin targeting mesothelin, a cell-surface antigen overexpressed in ovarian cancer and malignant mesothelioma.

Hassan R, Viner JL, Wang QC, Margulies I, Kreitman RJ, Pastan I. Hassan R, et al. Among authors: wang qc. J Immunother. 2000 Jul-Aug;23(4):473-9. doi: 10.1097/00002371-200007000-00011. J Immunother. 2000. PMID: 10916757

7

Inhibition of TNF-alpha produced by Kupffer cells protects against the nonspecific liver toxicity of immunotoxin anti-Tac(Fv)-PE38, LMB-2.

Onda M, Willingham M, Wang QC, Kreitman RJ, Tsutsumi Y, Nagata S, Pastan I. Onda M, et al. Among authors: wang qc. J Immunol. 2000 Dec 15;165(12):7150-6. doi: 10.4049/jimmunol.165.12.7150. J Immunol. 2000. PMID: 11120846

8

Eradication of tumor colonization and invasion by a B cell-specific immunotoxin in a murine model for human primary intraocular lymphoma.

Li Z, Mahesh SP, Shen DF, Liu B, Siu WO, Hwang FS, Wang QC, Chan CC, Pastan I, Nussenblatt RB. Li Z, et al. Among authors: wang qc. Cancer Res. 2006 Nov 1;66(21):10586-93. doi: 10.1158/0008-5472.CAN-06-1981. Cancer Res. 2006. PMID: 17079483 Free PMC article.

9

Intrathecal administration of single-chain immunotoxin, LMB-7 [B3(Fv)-PE38], produces cures of carcinomatous meningitis in a rat model.

Pastan IH, Archer GE, McLendon RE, Friedman HS, Fuchs HE, Wang QC, Pai LH, Herndon J, Bigner DD. Pastan IH, et al. Among authors: wang qc. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2765-9. doi: 10.1073/pnas.92.7.2765. Proc Natl Acad Sci U S A. 1995. PMID: 7708720 Free PMC article.

10

Pseudomonas exotoxin A mutants. Replacement of surface exposed residues in domain II with cysteine residues that can be modified with polyethylene glycol in a site-specific manner.

Kuan CT, Wang QC, Pastan I. Kuan CT, et al. Among authors: wang qc. J Biol Chem. 1994 Mar 11;269(10):7610-6. J Biol Chem. 1994. PMID: 8125985 Free article.

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