Bristow L - Search Results

1

Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.

McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ. McKernan RM, et al. Among authors: bristow l. Nat Neurosci. 2000 Jun;3(6):587-92. doi: 10.1038/75761. Nat Neurosci. 2000. PMID: 10816315

2

TPA023 [7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine], an agonist selective for alpha2- and alpha3-containing GABAA receptors, is a nonsedating anxiolytic in rodents and primates.

Atack JR, Wafford KA, Tye SJ, Cook SM, Sohal B, Pike A, Sur C, Melillo D, Bristow L, Bromidge F, Ragan I, Kerby J, Street L, Carling R, Castro JL, Whiting P, Dawson GR, McKernan RM. Atack JR, et al. Among authors: bristow l. J Pharmacol Exp Ther. 2006 Jan;316(1):410-22. doi: 10.1124/jpet.105.089920. Epub 2005 Sep 23. J Pharmacol Exp Ther. 2006. PMID: 16183706

3

Contextual fear conditioning and baseline startle responses in the rat fear-potentiated startle test: a comparison of benzodiazepine/gamma-aminobutyric acid-A receptor agonists.

Guscott MR, Cook GP, Bristow LJ. Guscott MR, et al. Among authors: bristow lj. Behav Pharmacol. 2000 Sep;11(6):495-504. doi: 10.1097/00008877-200009000-00006. Behav Pharmacol. 2000. PMID: 11103915

4

Genetic knockout and pharmacological blockade studies of the 5-HT7 receptor suggest therapeutic potential in depression.

Guscott M, Bristow LJ, Hadingham K, Rosahl TW, Beer MS, Stanton JA, Bromidge F, Owens AP, Huscroft I, Myers J, Rupniak NM, Patel S, Whiting PJ, Hutson PH, Fone KC, Biello SM, Kulagowski JJ, McAllister G. Guscott M, et al. Among authors: bristow lj. Neuropharmacology. 2005 Mar;48(4):492-502. doi: 10.1016/j.neuropharm.2004.11.015. Neuropharmacology. 2005. PMID: 15755477

5

L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests.

Bristow LJ, Collinson N, Cook GP, Curtis N, Freedman SB, Kulagowski JJ, Leeson PD, Patel S, Ragan CI, Ridgill M, Saywell KL, Tricklebank MD. Bristow LJ, et al. J Pharmacol Exp Ther. 1997 Dec;283(3):1256-63. J Pharmacol Exp Ther. 1997. PMID: 9400001

6

Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist.

Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR. Bristow LJ, et al. Trends Pharmacol Sci. 1997 Jun;18(6):186-8. doi: 10.1016/s0165-6147(97)01066-3. Trends Pharmacol Sci. 1997. PMID: 9226994 Review.

7

Discriminative stimulus properties of the putative dopamine D3 receptor agonist, (+)-PD 128907: role of presynaptic dopamine D2 autoreceptors.

Bristow LJ, Cook GP, Patel S, Curtis N, Mawer I, Kulagowski JJ. Bristow LJ, et al. Neuropharmacology. 1998 Jun;37(6):793-802. doi: 10.1016/s0028-3908(98)00066-5. Neuropharmacology. 1998. PMID: 9707293

8

Identification of 3,5-dihydro-2-aryl-1H-pyrazolo[3,4-c]quinoline-1,4(2H)-diones as novel high-affinity glycine site N-methyl-D-aspartate antagonists.

MacLeod AM, Grimwood S, Barton C, Bristow L, Saywell KL, Marshall GR, Ball RG. MacLeod AM, et al. Among authors: bristow l. J Med Chem. 1995 Jun 9;38(12):2239-43. doi: 10.1021/jm00012a024. J Med Chem. 1995. PMID: 7783155

9

N-Arylsulfonylindole derivatives as serotonin 5-HT(6) receptor ligands.

Russell MG, Baker RJ, Barden L, Beer MS, Bristow L, Broughton HB, Knowles M, McAllister G, Patel S, Castro JL. Russell MG, et al. Among authors: bristow l. J Med Chem. 2001 Nov 8;44(23):3881-95. doi: 10.1021/jm010943m. J Med Chem. 2001. PMID: 11689074

10

Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.

Patel S, Freedman S, Chapman KL, Emms F, Fletcher AE, Knowles M, Marwood R, Mcallister G, Myers J, Curtis N, Kulagowski JJ, Leeson PD, Ridgill M, Graham M, Matheson S, Rathbone D, Watt AP, Bristow LJ, Rupniak NM, Baskin E, Lynch JJ, Ragan CI. Patel S, et al. Among authors: bristow lj. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47. J Pharmacol Exp Ther. 1997. PMID: 9353380

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