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Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ. McKernan RM, et al. Among authors: cook g. Nat Neurosci. 2000 Jun;3(6):587-92. doi: 10.1038/75761. Nat Neurosci. 2000. PMID: 10816315
The hypothermic effect of 5-CT in mice is mediated through the 5-HT7 receptor.
Guscott MR, Egan E, Cook GP, Stanton JA, Beer MS, Rosahl TW, Hartmann S, Kulagowski J, McAllister G, Fone KC, Hutson PH. Guscott MR, et al. Among authors: cook gp. Neuropharmacology. 2003 Jun;44(8):1031-7. doi: 10.1016/s0028-3908(03)00117-5. Neuropharmacology. 2003. PMID: 12763096
4-(Phenylsulfonyl)piperidines: novel, selective, and bioavailable 5-HT(2A) receptor antagonists.
Fletcher SR, Burkamp F, Blurton P, Cheng SK, Clarkson R, O'Connor D, Spinks D, Tudge M, van Niel MB, Patel S, Chapman K, Marwood R, Shepheard S, Bentley G, Cook GP, Bristow LJ, Castro JL, Hutson PH, MacLeod AM. Fletcher SR, et al. Among authors: cook gp. J Med Chem. 2002 Jan 17;45(2):492-503. doi: 10.1021/jm011030v. J Med Chem. 2002. PMID: 11784153
2,046 results