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Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABA(A) receptor alpha1 subtype.
McKernan RM, Rosahl TW, Reynolds DS, Sur C, Wafford KA, Atack JR, Farrar S, Myers J, Cook G, Ferris P, Garrett L, Bristow L, Marshall G, Macaulay A, Brown N, Howell O, Moore KW, Carling RW, Street LJ, Castro JL, Ragan CI, Dawson GR, Whiting PJ. McKernan RM, et al. Among authors: ferris p. Nat Neurosci. 2000 Jun;3(6):587-92. doi: 10.1038/75761. Nat Neurosci. 2000. PMID: 10816315
Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety.
Russell MG, Carling RW, Street LJ, Hallett DJ, Goodacre S, Mezzogori E, Reader M, Cook SM, Bromidge FA, Newman R, Smith AJ, Wafford KA, Marshall GR, Reynolds DS, Dias R, Ferris P, Stanley J, Lincoln R, Tye SJ, Sheppard WF, Sohal B, Pike A, Dominguez M, Atack JR, Castro JL. Russell MG, et al. Among authors: ferris p. J Med Chem. 2006 Feb 23;49(4):1235-8. doi: 10.1021/jm051200u. J Med Chem. 2006. PMID: 16480260
Genetic mapping of variation in spatial learning in the mouse.
Steinberger D, Reynolds DS, Ferris P, Lincoln R, Datta S, Stanley J, Paterson A, Dawson GR, Flint J. Steinberger D, et al. Among authors: ferris p. J Neurosci. 2003 Mar 15;23(6):2426-33. doi: 10.1523/JNEUROSCI.23-06-02426.2003. J Neurosci. 2003. PMID: 12657702 Free PMC article.
Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial.
Dark P, Hossain A, McAuley DF, Brealey D, Carlson G, Clayton JC, Felton TW, Ghuman BK, Gordon AC, Hellyer TP, Lone NI, Manazar U, Richards G, McCullagh IJ, McMullan R, McNamee JJ, McNeil HC, Mouncey PR, Naisbitt MJ, Parker RJ, Poole RL, Rostron AJ, Singer M, Stevenson MD, Walsh TS, Welters ID, Whitehouse T, Whiteley S, Wilson P, Young KK, Perkins GD, Lall R; ADAPT-Sepsis Collaborators. Dark P, et al. JAMA. 2024 Dec 9. doi: 10.1001/jama.2024.26458. Online ahead of print. JAMA. 2024. PMID: 39652885
84 results