Missbach M - Search Results

1

Substituted 5,7-diphenyl-pyrrolo[2,3d]pyrimidines: potent inhibitors of the tyrosine kinase c-Src.

Missbach M, Altmann E, Widler L, Susa M, Buchdunger E, Mett H, Meyer T, Green J. Missbach M, et al. Bioorg Med Chem Lett. 2000 May 1;10(9):945-9. doi: 10.1016/s0960-894x(00)00131-1. Bioorg Med Chem Lett. 2000. PMID: 10853665

2

N(7)-substituted-5-aryl-pyrrolo[2,3-d]pyrimidines represent a versatile class of potent inhibitors of the tyrosine kinase c-Src.

Altmann E, Widler L, Missbach M. Altmann E, et al. Among authors: missbach m. Mini Rev Med Chem. 2002 Jun;2(3):201-8. doi: 10.2174/1389557023406188. Mini Rev Med Chem. 2002. PMID: 12370062 Review.

3

Dipeptide nitrile inhibitors of cathepsin K.

Altmann E, Aichholz R, Betschart C, Buhl T, Green J, Lattmann R, Missbach M. Altmann E, et al. Among authors: missbach m. Bioorg Med Chem Lett. 2006 May 1;16(9):2549-54. doi: 10.1016/j.bmcl.2006.01.104. Epub 2006 Feb 9. Bioorg Med Chem Lett. 2006. PMID: 16480867

4

2-Cyano-pyrimidines: a new chemotype for inhibitors of the cysteine protease cathepsin K.

Altmann E, Aichholz R, Betschart C, Buhl T, Green J, Irie O, Teno N, Lattmann R, Tintelnot-Blomley M, Missbach M. Altmann E, et al. Among authors: missbach m. J Med Chem. 2007 Feb 22;50(4):591-4. doi: 10.1021/jm0613525. Epub 2007 Jan 27. J Med Chem. 2007. PMID: 17256925

5

Penta-substituted benzimidazoles as potent antagonists of the calcium-sensing receptor (CaSR-antagonists).

Gerspacher M, Altmann E, Beerli R, Buhl T, Endres R, Gamse R, Kameni-Tcheudji J, Kneissel M, Krawinkler KH, Missbach M, Schmidt A, Seuwen K, Weiler S, Widler L. Gerspacher M, et al. Among authors: missbach m. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5161-4. doi: 10.1016/j.bmcl.2010.07.016. Epub 2010 Aug 3. Bioorg Med Chem Lett. 2010. PMID: 20685119

6

A novel inhibitor of the tyrosine kinase Src suppresses phosphorylation of its major cellular substrates and reduces bone resorption in vitro and in rodent models in vivo.

Missbach M, Jeschke M, Feyen J, Müller K, Glatt M, Green J, Susa M. Missbach M, et al. Bone. 1999 May;24(5):437-49. doi: 10.1016/s8756-3282(99)00020-4. Bone. 1999. PMID: 10321903

7

Active recombinant human tyrosine kinase c-Yes: expression in baculovirus system, purification, comparison to c-Src, and inhibition by a c-Src inhibitor.

Susa M, Luong-Nguyen NH, Crespo J, Maier R, Missbach M, McMaster G. Susa M, et al. Among authors: missbach m. Protein Expr Purif. 2000 Jun;19(1):99-106. doi: 10.1006/prep.2000.1221. Protein Expr Purif. 2000. PMID: 10833396

8

7-Alkyl- and 7-cycloalkyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.

Widler L, Green J, Missbach M, Susa M, Altmann E. Widler L, et al. Among authors: missbach m. Bioorg Med Chem Lett. 2001 Mar 26;11(6):849-52. doi: 10.1016/s0960-894x(01)00079-8. Bioorg Med Chem Lett. 2001. PMID: 11277535

9

7-Pyrrolidinyl- and 7-piperidinyl-5-aryl-pyrrolo[2,3-d]pyrimidines--potent inhibitors of the tyrosine kinase c-Src.

Altmann E, Missbach M, Green J, Susa M, Wagenknecht HA, Widler L. Altmann E, et al. Among authors: missbach m. Bioorg Med Chem Lett. 2001 Mar 26;11(6):853-6. doi: 10.1016/s0960-894x(01)00080-4. Bioorg Med Chem Lett. 2001. PMID: 11277536

10

Tyrosine kinase inhibition in bone metabolism.

Missbach M, Altmann E, Susa M. Missbach M, et al. Curr Opin Drug Discov Devel. 2000 Sep;3(5):541-8. Curr Opin Drug Discov Devel. 2000. PMID: 19649882

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