Champeroux P - Search Results

1

The preclinical assessment of the risk for QT interval prolongation.

Champeroux P, Martel E, Vannier C, Blanc V, Leguennec JY, Fowler J, Richard S. Champeroux P, et al. Therapie. 2000 Jan-Feb;55(1):101-9. Therapie. 2000. PMID: 10860008 Review.

2

Interferences of the autonomic nervous system with drug induced QT prolongation: a point to consider in non-clinical safety studies.

Champeroux P, Ouillé A, Martel E, Fowler JS, Maurin A, Jude S, Lala P, Le Guennec JY, Richard S. Champeroux P, et al. J Pharmacol Toxicol Methods. 2010 May-Jun;61(3):251-63. doi: 10.1016/j.vascn.2010.02.006. Epub 2010 Feb 19. J Pharmacol Toxicol Methods. 2010. PMID: 20172034

3

Prediction of the risk of Torsade de Pointes using the model of isolated canine Purkinje fibres.

Champeroux P, Viaud K, El Amrani AI, Fowler JS, Martel E, Le Guennec JY, Richard S. Champeroux P, et al. Br J Pharmacol. 2005 Feb;144(3):376-85. doi: 10.1038/sj.bjp.0706070. Br J Pharmacol. 2005. PMID: 15655517 Free PMC article.

4

Calculation of QT shift in non clinical safety pharmacology studies.

Champeroux P, Martel E, Fowler JS, Maurin A, Sola ML, Jude S, Elamrani F, Weyn AA, Laveissiere A, Lala P, Richard S. Champeroux P, et al. J Pharmacol Toxicol Methods. 2009 Mar-Apr;59(2):73-85. doi: 10.1016/j.vascn.2008.11.001. Epub 2008 Dec 10. J Pharmacol Toxicol Methods. 2009. PMID: 19135537

5

A step towards characterisation of electrophysiological profile of torsadogenic drugs.

Champeroux P, Ouillé A, Martel E, Fowler JS, Maurin A, Richard S, Le Guennec JY. Champeroux P, et al. J Pharmacol Toxicol Methods. 2011 May-Jun;63(3):269-78. doi: 10.1016/j.vascn.2011.01.001. Epub 2011 Jan 9. J Pharmacol Toxicol Methods. 2011. PMID: 21224008

6

Contribution of haemodynamic side effects and associated autonomic reflexes to ventricular arrhythmias triggering by torsadogenic hERG blocking drugs.

Champéroux P, Fares R, Bastogne T, Richard S, Le Guennec JY, Thireau J. Champéroux P, et al. Br J Pharmacol. 2022 Sep;179(18):4549-4562. doi: 10.1111/bph.15905. Epub 2022 Jul 13. Br J Pharmacol. 2022. PMID: 35751378 Free PMC article.

7

Short-term variability in QT interval and ventricular arrhythmias induced by dofetilide are dependent on high-frequency autonomic oscillations.

Champeroux P, Thireau J, Judé S, Laigot-Barbé C, Maurin A, Sola ML, Fowler JS, Richard S, Le Guennec JY. Champeroux P, et al. Br J Pharmacol. 2015 Jun;172(11):2878-91. doi: 10.1111/bph.13093. Epub 2015 Mar 26. Br J Pharmacol. 2015. PMID: 25625756 Free PMC article.

8

Power spectral analysis of heart rate variability in cynomolgus monkeys in safety pharmacology studies: comparative study with beagle dogs.

Champeroux P, Martel E, Jude S, Laigot C, Laveissière A, Weyn-Marotte AA, Fowler JS, Maurin A, Richard S, Babuty D. Champeroux P, et al. J Pharmacol Toxicol Methods. 2013 Jul-Aug;68(1):166-74. doi: 10.1016/j.vascn.2013.02.005. Epub 2013 Feb 19. J Pharmacol Toxicol Methods. 2013. PMID: 23435316

9

The Complex QT/RR Relationship in Mice.

Roussel J, Champeroux P, Roy J, Richard S, Fauconnier J, Le Guennec JY, Thireau J. Roussel J, et al. Among authors: champeroux p. Sci Rep. 2016 May 3;6:25388. doi: 10.1038/srep25388. Sci Rep. 2016. PMID: 27138175 Free PMC article.

10

Inter-individual variability and modeling of electrical activity: a possible new approach to explore cardiac safety?

Le Guennec JY, Thireau J, Ouillé A, Roussel J, Roy J, Richard S, Richard S, Martel E, Champéroux P. Le Guennec JY, et al. Among authors: champeroux p. Sci Rep. 2016 Nov 30;6:37948. doi: 10.1038/srep37948. Sci Rep. 2016. PMID: 27901061 Free PMC article.

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