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Megakaryocyte precursors, megakaryocytes and platelets express the HIV co-receptor CXCR4 on their surface: determination of response to stromal-derived factor-1 by megakaryocytes and platelets.
Kowalska MA, Ratajczak J, Hoxie J, Brass LF, Gewirtz A, Poncz M, Ratajczak MZ. Kowalska MA, et al. Among authors: ratajczak j, ratajczak mz. Br J Haematol. 1999 Feb;104(2):220-9. doi: 10.1046/j.1365-2141.1999.01169.x. Br J Haematol. 1999. PMID: 10050701 Free article.
Binding of stromal derived factor-1alpha (SDF-1alpha) to CXCR4 chemokine receptor in normal human megakaryoblasts but not in platelets induces phosphorylation of mitogen-activated protein kinase p42/44 (MAPK), ELK-1 transcription factor and serine/threonine kinase AKT.
Majka M, Ratajczak J, Kowalska MA, Ratajczak MZ. Majka M, et al. Among authors: ratajczak j, ratajczak mz. Eur J Haematol. 2000 Mar;64(3):164-72. doi: 10.1034/j.1600-0609.2000.90112.x. Eur J Haematol. 2000. PMID: 10997882
Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner.
Majka M, Janowska-Wieczorek A, Ratajczak J, Ehrenman K, Pietrzkowski Z, Kowalska MA, Gewirtz AM, Emerson SG, Ratajczak MZ. Majka M, et al. Among authors: ratajczak j, ratajczak mz. Blood. 2001 May 15;97(10):3075-85. doi: 10.1182/blood.v97.10.3075. Blood. 2001. PMID: 11342433 Free article.
Chemokine regulation of human megakaryocytopoiesis.
Gewirtz AM, Zhang J, Ratajczak J, Ratajczak M, Park KS, Li C, Yan Z, Poncz M. Gewirtz AM, et al. Blood. 1995 Oct 1;86(7):2559-67. Blood. 1995. PMID: 7670101 Free article.
535 results