Wolfe MS - Search Results

1

Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling.

Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Berezovska O, et al. Among authors: wolfe ms. J Neurochem. 2000 Aug;75(2):583-93. doi: 10.1046/j.1471-4159.2000.0750583.x. J Neurochem. 2000. PMID: 10899933 Free article.

2

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

Wolfe MS, Citron M, Diehl TS, Xia W, Donkor IO, Selkoe DJ. Wolfe MS, et al. J Med Chem. 1998 Jan 1;41(1):6-9. doi: 10.1021/jm970621b. J Med Chem. 1998. PMID: 9438016 No abstract available.

3

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.

Wolfe MS, Xia W, Moore CL, Leatherwood DD, Ostaszewski B, Rahmati T, Donkor IO, Selkoe DJ. Wolfe MS, et al. Biochemistry. 1999 Apr 13;38(15):4720-7. doi: 10.1021/bi982562p. Biochemistry. 1999. PMID: 10200159

4

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ. Wolfe MS, et al. Nature. 1999 Apr 8;398(6727):513-7. doi: 10.1038/19077. Nature. 1999. PMID: 10206644

5

Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease.

Wolfe MS, De Los Angeles J, Miller DD, Xia W, Selkoe DJ. Wolfe MS, et al. Biochemistry. 1999 Aug 31;38(35):11223-30. doi: 10.1021/bi991080q. Biochemistry. 1999. PMID: 10471271 Review.

6

Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch.

Ray WJ, Yao M, Mumm J, Schroeter EH, Saftig P, Wolfe M, Selkoe DJ, Kopan R, Goate AM. Ray WJ, et al. J Biol Chem. 1999 Dec 17;274(51):36801-7. doi: 10.1074/jbc.274.51.36801. J Biol Chem. 1999. PMID: 10593990 Free article.

7

The transmembrane aspartates in presenilin 1 and 2 are obligatory for gamma-secretase activity and amyloid beta-protein generation.

Kimberly WT, Xia W, Rahmati T, Wolfe MS, Selkoe DJ. Kimberly WT, et al. Among authors: wolfe ms. J Biol Chem. 2000 Feb 4;275(5):3173-8. doi: 10.1074/jbc.275.5.3173. J Biol Chem. 2000. PMID: 10652302 Free article.

8

In search of gamma-secretase: presenilin at the cutting edge.

Selkoe DJ, Wolfe MS. Selkoe DJ, et al. Among authors: wolfe ms. Proc Natl Acad Sci U S A. 2000 May 23;97(11):5690-2. doi: 10.1073/pnas.97.11.5690. Proc Natl Acad Sci U S A. 2000. PMID: 10823929 Free PMC article. No abstract available.

9

Transition-state analogue inhibitors of gamma-secretase bind directly to presenilin-1.

Esler WP, Kimberly WT, Ostaszewski BL, Diehl TS, Moore CL, Tsai JY, Rahmati T, Xia W, Selkoe DJ, Wolfe MS. Esler WP, et al. Among authors: wolfe ms. Nat Cell Biol. 2000 Jul;2(7):428-34. doi: 10.1038/35017062. Nat Cell Biol. 2000. PMID: 10878808

10

Presenilin complexes with the C-terminal fragments of amyloid precursor protein at the sites of amyloid beta-protein generation.

Xia W, Ray WJ, Ostaszewski BL, Rahmati T, Kimberly WT, Wolfe MS, Zhang J, Goate AM, Selkoe DJ. Xia W, et al. Among authors: wolfe ms. Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9299-304. doi: 10.1073/pnas.97.16.9299. Proc Natl Acad Sci U S A. 2000. PMID: 10922078 Free PMC article.

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