Patterson AV - Search Results

1

Induction of thymidine phosphorylase as a pharmacodynamic end-point in patients with advanced carcinoma treated with 5-fluorouracil, folinic acid and interferon alpha.

Braybrooke JP, Propper DJ, O'Byrne KJ, Koukourakis MI, Patterson AV, Houlbrook S, Love SD, Varcoe S, Taylor M, Ganesan TS, Talbot DC, Harris AL. Braybrooke JP, et al. Among authors: patterson av. Br J Cancer. 2000 Jul;83(2):219-24. doi: 10.1054/bjoc.2000.1230. Br J Cancer. 2000. PMID: 10901374 Free PMC article. Clinical Trial.

2

Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.

Patterson AV, Zhang H, Moghaddam A, Bicknell R, Talbot DC, Stratford IJ, Harris AL. Patterson AV, et al. Br J Cancer. 1995 Sep;72(3):669-75. doi: 10.1038/bjc.1995.392. Br J Cancer. 1995. PMID: 7669579 Free PMC article.

3

Overexpression of human NADPH:cytochrome c (P450) reductase confers enhanced sensitivity to both tirapazamine (SR 4233) and RSU 1069.

Patterson AV, Saunders MP, Chinje EC, Talbot DC, Harris AL, Strafford IJ. Patterson AV, et al. Br J Cancer. 1997;76(10):1338-47. doi: 10.1038/bjc.1997.558. Br J Cancer. 1997. PMID: 9374381 Free PMC article.

4

Thymidine phosphorylase moderates thymidine-dependent rescue after exposure to the thymidylate synthase inhibitor ZD1694 (Tomudex) in vitro.

Patterson AV, Talbot DC, Stratford IJ, Harris AL. Patterson AV, et al. Cancer Res. 1998 Jul 1;58(13):2737-40. Cancer Res. 1998. PMID: 9661884

5

Does reductive metabolism predict response to tirapazamine (SR 4233) in human non-small-cell lung cancer cell lines?

Chinje EC, Patterson AV, Saunders MP, Lockyer SD, Harris AL, Stratford IJ. Chinje EC, et al. Among authors: patterson av. Br J Cancer. 1999 Dec;81(7):1127-33. doi: 10.1038/sj.bjc.6690819. Br J Cancer. 1999. PMID: 10584872 Free PMC article.

6

Importance of P450 reductase activity in determining sensitivity of breast tumour cells to the bioreductive drug, tirapazamine (SR 4233).

Patterson AV, Barham HM, Chinje EC, Adams GE, Harris AL, Stratford IJ. Patterson AV, et al. Br J Cancer. 1995 Nov;72(5):1144-50. doi: 10.1038/bjc.1995.478. Br J Cancer. 1995. PMID: 7577460 Free PMC article.

7

NADPH:cytochrome c (P450) reductase activates tirapazamine (SR4233) to restore hypoxic and oxic cytotoxicity in an aerobic resistant derivative of the A549 lung cancer cell line.

Saunders MP, Patterson AV, Chinje EC, Harris AL, Stratford IJ. Saunders MP, et al. Among authors: patterson av. Br J Cancer. 2000 Feb;82(3):651-6. doi: 10.1054/bjoc.1999.0977. Br J Cancer. 2000. PMID: 10682679 Free PMC article.

8

Molecular chemotherapy for breast cancer.

Patterson A, Harris AL. Patterson A, et al. Drugs Aging. 1999 Feb;14(2):75-90. doi: 10.2165/00002512-199914020-00001. Drugs Aging. 1999. PMID: 10084362 Review.

9

The role of DT-diaphorase in determining the sensitivity of human tumor cells to tirapazamine (SR 4233).

Patterson AV, Robertson N, Houlbrook S, Stephens MA, Adams GE, Harris AL, Stratford IJ, Carmichael J. Patterson AV, et al. Int J Radiat Oncol Biol Phys. 1994 May 15;29(2):369-72. doi: 10.1016/0360-3016(94)90291-7. Int J Radiat Oncol Biol Phys. 1994. PMID: 8195035

10

Targeting gene expression to hypoxic tumor cells.

Dachs GU, Patterson AV, Firth JD, Ratcliffe PJ, Townsend KM, Stratford IJ, Harris AL. Dachs GU, et al. Among authors: patterson av. Nat Med. 1997 May;3(5):515-20. doi: 10.1038/nm0597-515. Nat Med. 1997. PMID: 9142119

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