García-Echeverría C - Search Results

1

Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53.

García-Echeverría C, Chène P, Blommers MJ, Furet P. García-Echeverría C, et al. J Med Chem. 2000 Aug 24;43(17):3205-8. doi: 10.1021/jm990966p. J Med Chem. 2000. PMID: 10966738 No abstract available.

2

Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells.

Chène P, Fuchs J, Carena I, Furet P, García-Echeverría C. Chène P, et al. FEBS Lett. 2002 Oct 9;529(2-3):293-7. doi: 10.1016/s0014-5793(02)03362-8. FEBS Lett. 2002. PMID: 12372616 Free article.

3

Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.

García-Echeverría C, Furet P, Gay B, Fretz H, Rahuel J, Schoepfer J, Caravatti G. García-Echeverría C, et al. J Med Chem. 1998 May 21;41(11):1741-4. doi: 10.1021/jm970856n. J Med Chem. 1998. PMID: 9599224 No abstract available.

4

Structure-based design and synthesis of high affinity tripeptide ligands of the Grb2-SH2 domain.

Furet P, Gay B, Caravatti G, García-Echeverría C, Rahuel J, Schoepfer J, Fretz H. Furet P, et al. J Med Chem. 1998 Aug 27;41(18):3442-9. doi: 10.1021/jm980159a. J Med Chem. 1998. PMID: 9719597

5

Structure-based design, synthesis, and X-ray crystallography of a high-affinity antagonist of the Grb2-SH2 domain containing an asparagine mimetic.

Furet P, García-Echeverría C, Gay B, Schoepfer J, Zeller M, Rahuel J. Furet P, et al. J Med Chem. 1999 Jul 1;42(13):2358-63. doi: 10.1021/jm991013u. J Med Chem. 1999. PMID: 10395476

6

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines.

Chène P, Fuchs J, Bohn J, García-Echeverría C, Furet P, Fabbro D. Chène P, et al. J Mol Biol. 2000 May 26;299(1):245-53. doi: 10.1006/jmbi.2000.3738. J Mol Biol. 2000. PMID: 10860736

7

A new structural class of selective and non-covalent inhibitors of the chymotrypsin-like activity of the 20S proteasome.

García-Echeverría C, Imbach P, France D, Fürst P, Lang M, Noorani AM, Scholz D, Zimmermann J, Furet P. García-Echeverría C, et al. Bioorg Med Chem Lett. 2001 May 21;11(10):1317-9. doi: 10.1016/s0960-894x(01)00205-0. Bioorg Med Chem Lett. 2001. PMID: 11392545

8

Modeling of the binding mode of a non-covalent inhibitor of the 20S proteasome. Application to structure-based analogue design.

Furet P, Imbach P, Fürst P, Lang M, Noorani M, Zimmermann J, García-Echeverria C. Furet P, et al. Bioorg Med Chem Lett. 2001 May 21;11(10):1321-4. doi: 10.1016/s0960-894x(01)00206-2. Bioorg Med Chem Lett. 2001. PMID: 11392546

9

Coupling of the antennapedia third helix to a potent antagonist of the p53/hdm2 protein-protein interaction.

García-Echeverría C, Furet P, Chène P. García-Echeverría C, et al. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2161-4. doi: 10.1016/s0960-894x(01)00394-8. Bioorg Med Chem Lett. 2001. PMID: 11514160

10

Structure-based optimisation of 2-aminobenzylstatine derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

Furet P, Imbach P, Fuerst P, Lang M, Noorani M, Zimmermann J, García-Echeverría C. Furet P, et al. Bioorg Med Chem Lett. 2002 May 20;12(10):1331-4. doi: 10.1016/s0960-894x(02)00178-6. Bioorg Med Chem Lett. 2002. PMID: 11992770

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